Chemical structure of posttranslational modification with a farnesyl group on tryptophan.

Chemical structure of posttranslational modification with a farnesyl group on tryptophan. Research Abstract Details 

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Chemical structure of posttranslational modification with a farnesyl group on tryptophan. Abstract Text:

Masahiro Okada,Hisao Yamaguchi,Isao Sato,Fumitada Tsuji,David Dubnau,Youji Sakagami,

Bacillus subtilis and related bacilli produce a posttranslationally modified oligopeptide, the ComX pheromone, that stimulates natural genetic competence controlled by quorum sensing. The ComX(RO-C-2) pheromone from strain RO-C-2 must be modified with a farnesyl group on the Trp residue, but the precise structure is not known. Here we report the precise nature of posttranslational farnesylation of ComX(RO-C-2) pheromone on the Trp residue, resulting in the formation of a tricyclic structure. The ComX(168) pheromone, produced by the standard laboratory strain used in the study of B. subtilis, is also posttranslationally farnesylated according to phylogenetic resemblance.

Chemical structure of posttranslational modification with a farnesyl group on tryptophan. Publishing Authors By Initials

M Okada,H Yamaguchi,I Sato,F Tsuji,D Dubnau,Y Sakagami,

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Chemical structure of posttranslational modification with a farnesyl group on tryptophan. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bioscience, biotechnology, and biochemistry

VOLUME: 72

Page Numbers: 914-8

Journal Abbreviation: Biosci. Biotechnol. Biochem.

ISSN: 1347-6947

DAY: 7

MONTH: 03

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 9205717

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Grant and Affiliation Information for Chemical structure of posttranslational modification with a farnesyl group on tryptophan.

AFFILIATION: Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464-8601, Japan.

Country: Japan

AGENCY: United States NIGMS

GRANT: GM057720

ACRONYM: GM

MEDLINETA: Biosci Biotechnol Biochem

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