Chemical genetic screening identifies a novel inhibitor of parallel alignment of cortical microtubules and cellulose microfibrils.

Chemical genetic screening identifies a novel inhibitor of parallel alignment of cortical microtubules and cellulose microfibrils. Research Abstract Details 

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Chemical genetic screening identifies a novel inhibitor of parallel alignment of cortical microtubules and cellulose microfibrils. Abstract Text:

Arata Yoneda,Takumi Higaki,Natsumaro Kutsuna,Yoichi Kondo,Hiroyuki Osada,Seiichiro Hasezawa,Minami Matsui,Arata Yoneda,Takumi Higaki,Natsumaro Kutsuna,Yoichi Kondo,Hiroyuki Osada,Seiichiro Hasezawa,Minami Matsui,

It is a well-known hypothesis that cortical microtubules control the direction of cellulose microfibril deposition, and that the parallel cellulose microfibrils determine anisotropic cell expansion and plant cell morphogenesis. However, the molecular mechanism by which cortical microtubules regulate the orientation of cellulose microfibrils is still unclear. To investigate this mechanism, chemical genetic screening was performed. From this screening, 'SS compounds' were identified that induced a spherical swelling phenotype in tobacco BY-2 cells. The SS compounds could be categorized into three classes: those that disrupted the cortical microtubules; those that reduced cellulose microfibril content; and thirdly those that had neither of these effects. In the last class, a chemical designated 'cobtorin' was found to induce the spherical swelling phenotype at the lowest concentration, suggesting strong binding activity to the putative target. Examining cellulose microfibril regeneration using taxol-treated protoplasts revealed that the cobtorin compound perturbed the parallel alignment of pre-existing cortical microtubules and nascent cellulose microfibrils. Thus, cobtorin could be a novel inhibitor and an attractive tool for further investigation of the mechanism that enables cortical microtubules to guide the parallel deposition of cellulose microfibrils.

Chemical genetic screening identifies a novel inhibitor of parallel alignment of cortical microtubules and cellulose microfibrils. Publishing Authors By Initials

A Yoneda,T Higaki,N Kutsuna,Y Kondo,H Osada,S Hasezawa,M Matsui,A Yoneda,T Higaki,N Kutsuna,Y Kondo,H Osada,S Hasezawa,M Matsui,

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Chemical genetic screening identifies a novel inhibitor of parallel alignment of cortical microtubules and cellulose microfibrils. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Plant & cell physiology

VOLUME: 48

Page Numbers: 1393-403

Journal Abbreviation: Plant Cell Physiol.

ISSN: 0032-0781

DAY: 17

MONTH: 09

YEAR: 2007

Chemical genetic screening identifies a novel inhibitor of parallel alignment of cortical microtubules and cellulose microfibrils. Information

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LANGUAGE: eng

NlmUniqueID: 9430925

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Grant and Affiliation Information for Chemical genetic screening identifies a novel inhibitor of parallel alignment of cortical microtubules and cellulose microfibrils.

AFFILIATION: Plant Science Center, RIKEN, 1-7-22, Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0045 Japan.

Country: Japan

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MEDLINETA: Plant Cell Physiol

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