Chemical analysis of norrisolide-induced Golgi vesiculation.

Chemical analysis of norrisolide-induced Golgi vesiculation. Research Abstract Details 

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Chemical analysis of norrisolide-induced Golgi vesiculation. Abstract Text:

Gianni Guizzunti,Thomas P Brady,Vivek Malhotra,Emmanuel A Theodorakis,

The chemical origin of the norrisolide-induced irreversible Golgi vesiculation was studied using a variety of norrisolide probes. This natural product was found to bind to a receptor on the Golgi membranes using the perhydroindane core fragment as the recognition element. The acetylated gamma-lactol-gamma-lactone side chain of norrisolide is essential for the irreversible Golgi vesiculation and can be replaced by other electrophilic motifs without loss of biological function. In particular, compound 10 reproduces the cellular phenotype of the natural product.

Chemical analysis of norrisolide-induced Golgi vesiculation. Publishing Authors By Initials

G Guizzunti,TP Brady,V Malhotra,EA Theodorakis,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats research

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Chemical analysis of norrisolide-induced Golgi vesiculation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of the American Chemical Society

VOLUME: 128

Page Numbers: 4190-1

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 5

MONTH: Apr

YEAR: 2006

Chemical analysis of norrisolide-induced Golgi vesiculation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

Chemical analysis of norrisolide-induced Golgi vesiculation. Keywords Mesh Terms:

KEYWORDS: Rats

MESH TERMS: cytology

Chemical & Substance for Abstract: Chemical analysis of norrisolide-induced Golgi vesiculation. Information

Substance Name: norrisolide

Registry Number: 0

Grant and Affiliation Information for Chemical analysis of norrisolide-induced Golgi vesiculation.

AFFILIATION: Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, 92093-0358, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM 53747

ACRONYM: GM

MEDLINETA: J Am Chem Soc

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