Chemerin is a novel adipokine associated with obesity and metabolic syndrome.

Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Research Abstract Details 

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Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Abstract Text:

Kiymet Bozaoglu,Kristy Bolton,Janine McMillan,Paul Zimmet,Jeremy Jowett,Greg Collier,Ken Walder,David Segal,

Soluble protein hormones are key regulators of a number of metabolic processes, including food intake and insulin sensitivity. We have used a signal sequence trap to identify genes that encode secreted or membrane-bound proteins in Psammomys obesus, an animal model of obesity and type 2 diabetes (T2D). Using this signal sequence trap, we identified the chemokine chemerin as being a novel adipokine. Gene expression of chemerin and its receptor, chemokine-like receptor 1 (CMKLR1), was significantly higher in adipose tissue of obese and type 2 diabetic P. obesus compared with lean, normoglycemic P. obesus. Fractionation of P. obesus adipose tissue confirmed that chemerin was predominantly expressed in adipocytes, whereas CMKLR1 was expressed in both adipocytes and stromal-vascular cells of adipose tissue. In 3T3-L1 adipocytes, chemerin was markedly induced during differentiation, whereas CMKLR1 was down-regulated during differentiation. Serum chemerin levels were measured by ELISA in human plasma samples from 114 subjects with T2D and 142 normal glucose tolerant controls. Plasma chemerin levels were not significantly different between subjects with T2D and normal controls. However, in normal glucose tolerant subjects, plasma chemerin levels were significantly associated with body mass index, circulating triglycerides, and blood pressure. Here we report, for the first time, that chemerin is an adipokine, and circulating levels of chemerin are associated with several key aspects of metabolic syndrome.

Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Publishing Authors By Initials

K Bozaoglu,K Bolton,J McMillan,P Zimmet,J Jowett,G Collier,K Walder,D Segal,

For similar body regions: viscera research abstracts see: body regions: viscera research

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Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Endocrinology

VOLUME: 148

Page Numbers: 4687-94

Journal Abbreviation: Endocrinology

ISSN: 0013-7227

DAY: 19

MONTH: 07

YEAR: 2007

Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375040

Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Keywords Mesh Terms:

KEYWORDS: Viscera

MESH TERMS: metabolism

Chemical & Substance for Abstract: Chemerin is a novel adipokine associated with obesity and metabolic syndrome. Information

Substance Name: chemerin, human

Registry Number: 0

Grant and Affiliation Information for Chemerin is a novel adipokine associated with obesity and metabolic syndrome.

AFFILIATION: Metabolic Research Unit, School of Exercise and Nutrition Sciences, Deakin University, Pigdons Road, Waurn Ponds, Geelong, Victoria 3217, Australia.

Country: United States

AGENCY: United States NIDDK

GRANT: DK 25446

ACRONYM: DK

MEDLINETA: Endocrinology

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