Che-1/AATF, a multivalent adaptor connecting transcriptional regulation, checkpoint control, and apoptosis.

Che-1/AATF, a multivalent adaptor connecting transcriptional regulation, checkpoint control, and apoptosis. Research Abstract Details 

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Che-1/AATF, a multivalent adaptor connecting transcriptional regulation, checkpoint control, and apoptosis. Abstract Text:

Claudio Passananti,Aristide Floridi,Maurizio Fanciulli,Claudio Passananti,Aristide Floridi,Maurizio Fanciulli,

Che-1/AATF (Che-1) was originally characterized as an interacting protein for RNA polymerase II. In addition to transcriptional regulation, the evidence suggests that Che-1 has a viral factor-like S phase promoting role in counteracting Rb repression to facilitate E2F-dependent transactivation during G1-S transition. Recently, Che-1 was found to play an important role in the DNA damage response and cell-cycle checkpoint control. Genetic studies in mice revealed that Che-1 is essential for preimplantation development and the establishment of embryonic gene expression. Importantly, several findings showed that Che-1 participates in inhibiting apoptotic process. Thus, Che-1 emerges as an important adaptor that connects transcriptional regulation, cell-cycle progression, checkpoint control, and apoptosis.

Che-1/AATF, a multivalent adaptor connecting transcriptional regulation, checkpoint control, and apoptosis. Publishing Authors By Initials

C Passananti,A Floridi,M Fanciulli,C Passananti,A Floridi,M Fanciulli,

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Che-1/AATF, a multivalent adaptor connecting transcriptional regulation, checkpoint control, and apoptosis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemistry and cell biology = Biochimie et biolo

VOLUME: 85

Page Numbers: 477-83

Journal Abbreviation: Biochem. Cell Biol.

ISSN: 0829-8211

DAY: 23

MONTH: Aug

YEAR: 2007

Che-1/AATF, a multivalent adaptor connecting transcriptional regulation, checkpoint control, and apoptosis. Information

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LANGUAGE: eng

NlmUniqueID: 8606068

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Grant and Affiliation Information for Che-1/AATF, a multivalent adaptor connecting transcriptional regulation, checkpoint control, and apoptosis.

AFFILIATION: Istituto di Biologia e Patologia Molecolare, CNR, 00158 Rome, Italy.

Country: Canada

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MEDLINETA: Biochem Cell Biol

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