Charge-switching, amphoteric glucose-responsive microgels with physiological swelling activity.

Charge-switching, amphoteric glucose-responsive microgels with physiological swelling activity. Research Abstract Details 

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Charge-switching, amphoteric glucose-responsive microgels with physiological swelling activity. Abstract Text:

Todd Hoare,Robert Pelton,Todd Hoare,Robert Pelton,

Amphoteric, poly(N-isopropylacrylamide)-based microgels are functionalized with aminophenylboronic acid (PBA) functional groups to produce colloidally stable, glucose-responsive gel nanoparticles that exhibit glucose-dependent swelling responses at physiological temperature, pH, and ionic strength. Up to 2-fold volumetric swelling responses are observed in response to physiological glucose concentrations, the first such physiological response reported for a colloidally stable microgel. Amphoteric microgels can also be designed to both swell and deswell in response to glucose according to the pH of the medium, the concentration of PBA groups grafted to the microgel, and the relative concentrations of the cationic and anionic functional groups in the platform microgel. The increasing anionic charge density on the microgels observed at higher glucose binding fractions can be applied to switch the net charge of the microgels from cationic to anionic as the glucose concentration increases. Preliminary experiments suggest that such amphoteric PBA-microgels have a high capacity for insulin uptake and can selectively release more insulin at higher glucose concentrations under physiological conditions via glucose-induced, "on-off" switching of electrostatic attractions between insulin and the microgel.

Charge-switching, amphoteric glucose-responsive microgels with physiological swelling activity. Publishing Authors By Initials

T Hoare,R Pelton,T Hoare,R Pelton,

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Charge-switching, amphoteric glucose-responsive microgels with physiological swelling activity. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biomacromolecules

VOLUME: 9

Page Numbers: 733-40

Journal Abbreviation: Biomacromolecules

ISSN: 1526-4602

DAY: 17

MONTH: 01

YEAR: 2008

Charge-switching, amphoteric glucose-responsive microgels with physiological swelling activity. Information

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LANGUAGE: eng

NlmUniqueID: 100892849

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Grant and Affiliation Information for Charge-switching, amphoteric glucose-responsive microgels with physiological swelling activity.

AFFILIATION: Department of Chemical Engineering, McMaster University, 1280 Main St. W., Hamilton, Ontario, Canada L8S 4L7. hoaretr@mcmaster.ca

Country: United States

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MEDLINETA: Biomacromolecules

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