Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats.

Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats. Abstract Text:

Ana Guijarro,Susumu Suzuki,Chung Chen,Henriette Kirchner,Frank A Middleton,Sergiy Nadtochiy,Paul S Brookes,Akira Niijima,Akio Inui,Michael M Meguid,

Roux-en-Y gastric bypass (RYGB) is the most effective therapy for morbid obesity, but it has a approximately 20% failure rate. To test our hypothesis that outcome depends on differential modifications of several energy-related systems, we used our established RYGB model in Sprague-Dawley diet-induced obese (DIO) rats to determine mechanisms contributing to successful (RGYB-S) or failed (RYGB-F) RYGB. DIO rats were randomized to RYGB, sham-operated Obese, and sham-operated obese pair-fed linked to RYGB (PF) groups. Body weight (BW), caloric intake (CI), and fecal output (FO) were recorded daily for 90 days, food efficiency (FE) was calculated, and morphological changes were determined. d-Xylose and fat absorption were studied. Glucose-stimulated vagal efferent nerve firing rates of stomach were recorded. Gut, adipose, and thyroid hormones were measured in plasma. Mitochondrial respiratory complexes in skeletal muscle and expression of energy-related hypothalamic and fat peptides, receptors, and enzymes were quantified. A 25% failure rate occurred. RYGB-S, RYGB-F, and PF rats showed rapid BW decrease vs. Obese rats, followed by sustained BW loss in RYGB-S rats. RYGB-F and PF rats gradually increased BW. BW loss in RYGB-S rats is achieved not only by RYGB-induced decreased CI and increased FO, but also via sympathetic nervous system activation, driven by increased peptide YY, CRF, and orexin signaling, decreasing FE and energy storage, demonstrated by reduced fat mass associated with the upregulation of mitochondrial uncoupling protein-2 in fat. These events override the compensatory response to the drop in leptin levels aimed at conserving energy.

Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats. Publishing Authors By Initials

A Guijarro,S Suzuki,C Chen,H Kirchner,FA Middleton,S Nadtochiy,PS Brookes,A Niijima,A Inui,MM Meguid,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Regulatory, integr

VOLUME: 293

Page Numbers: R1474-89

Journal Abbreviation: Am. J. Physiol. Regul. Integr.

ISSN: 0363-6119

DAY: 11

MONTH: 07

YEAR: 2007

Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901230

Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats.

AFFILIATION: Dept. of Surgery, University Hospital, 750 East Adams St., Syracuse, NY 13210, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL-071158

ACRONYM: HL

MEDLINETA: Am J Physiol Regul Integr Comp

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats Related Publications

• Anatomic dissection of the arterial supply of the lips: an anatomical and analytical approach.
• Characterization of weight loss and weight regain mechanisms after Roux-en-Y gastric bypass in rats.
• Comparisons of body composition derived from anthropometric and bioelectrical impedance methods.
• High frequency-low morbidity mechanical complications of tube feeding: a prospective study.
• Hypothalamic integration of immune function and metabolism.
• In the matter of sex...sex matters in medical-scientific research.
• Influence of parenteral feeding on spontaneous caloric intake and food selection in rats.