Characterization of two glycoasparagines isolated from the urine of patients with aspartylglycosylaminuria (AGU).

Characterization of two glycoasparagines isolated from the urine of patients with aspartylglycosylaminuria (AGU). Research Abstract Details 

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Characterization of two glycoasparagines isolated from the urine of patients with aspartylglycosylaminuria (AGU). Abstract Text:

K Sugahara,S Funakoshi,I Funakoshi,P Aula,I Yamashina,

Two major glycoasparagines (2-acetamido-N-(4'-L-aspartyl)-2-deoxy-beta-D-glycosylamines) were isolated from the urine of patients with aspartylglycosylaminuria (AGU). They were composed of equimolar amounts of sialic acid, galactose, glucosamine, and aspartic acid. They were isomeric with respect to the position of sialic acid attachment, since they produced the same glycoasparagine on incubation with the neuraminidase from Clostridium perfringens. The structure of the resulting sialic acid-free glycoasparagine was determined as beta-Gal-(1 leads to 4)-beta-GlcNAc-Asn based on the following findings. It produced galactose on incubation with beta-galactosidase, and N-acetyllactosamine and aspartic acid on incubation with 4-L-aspartylglycosylamine amindo hydrolase.

Characterization of two glycoasparagines isolated from the urine of patients with aspartylglycosylaminuria (AGU). Publishing Authors By Initials

K Sugahara,S Funakoshi,I Funakoshi,P Aula,I Yamashina,

For similar organic chemicals: carboxylic acids: acids, acyclic: sugar acids: neuraminic acids: sialic acids research abstracts see: organic chemicals: carboxylic acids: acids, acyclic: sugar acids: neuraminic acids: sialic acids research

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Characterization of two glycoasparagines isolated from the urine of patients with aspartylglycosylaminuria (AGU). Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 78

Page Numbers: 673-8

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Oct

YEAR: 1975

Characterization of two glycoasparagines isolated from the urine of patients with aspartylglycosylaminuria (AGU). Information

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LANGUAGE: eng

NlmUniqueID: 376600

Characterization of two glycoasparagines isolated from the urine of patients with aspartylglycosylaminuria (AGU). Keywords Mesh Terms:

KEYWORDS: Sialic Acids

MESH TERMS: urine

Chemical & Substance for Abstract: Characterization of two glycoasparagines isolated from the urine of patients with aspartylglycosylaminuria (AGU). Information

Substance Name: Aspartylglucosylaminase

Registry Number: EC 3.5.1.26

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Country: JAPAN

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MEDLINETA: J Biochem

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