Characterization of the immunoglobulin A heavy chain gene of the Atlantic bottlenose dolphin (Tursiops truncatus).

Characterization of the immunoglobulin A heavy chain gene of the Atlantic bottlenose dolphin (Tursiops truncatus). Research Abstract Details 

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Characterization of the immunoglobulin A heavy chain gene of the Atlantic bottlenose dolphin (Tursiops truncatus). Abstract Text:

Annalaura Mancia,Tracy A Romano,Holly A Gefroh,Robert W Chapman,Darlene L Middleton,Gregory W Warr,Mats L Lundqvist,Annalaura Mancia,Tracy A Romano,Holly A Gefroh,Robert W Chapman,Darlene L Middleton,Gregory W Warr,Mats L Lundqvist,

Immunoglobulin constant region heavy chain genes of the dolphin (Tursiops truncatus) have been described for IgM and IgG but not for IgA. Here, the heavy chain sequence of dolphin IgA has been cloned and sequenced as cDNA. RT-PCR amplification from blood peripheral lymphocytes was carried out using degenerate primers and a single sequence was detected. The inferred heavy chain structure shows conserved features typical of mammalian IgA heavy chains, including three constant (C) regions, a hinge region between constant region domain 1 (C1) and constant region domain 2 (C2), and conserved residues for interaction with the Fc alpha R1 and N-glycosylation sites. Comparisons of the deduced amino acid sequences of the IgA heavy chain for the dolphin and the evolutionarily related artiodactyl species showed high similarity. In cattle and sheep, as in dolphins, a single IgA subclass has been identified. Southern blot analysis as well as genomic PCR confirmed the presence of multiple IGHA sequences suggesting that IGHA pseudogenes may be present in the dolphin genome.

Characterization of the immunoglobulin A heavy chain gene of the Atlantic bottlenose dolphin (Tursiops truncatus). Publishing Authors By Initials

A Mancia,TA Romano,HA Gefroh,RW Chapman,DL Middleton,GW Warr,ML Lundqvist,A Mancia,TA Romano,HA Gefroh,RW Chapman,DL Middleton,GW Warr,ML Lundqvist,

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Characterization of the immunoglobulin A heavy chain gene of the Atlantic bottlenose dolphin (Tursiops truncatus). Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Veterinary immunology and immunopathology

VOLUME: 118

Page Numbers: 304-9

Journal Abbreviation: Vet. Immunol. Immunopathol.

ISSN: 0165-2427

DAY: 3

MONTH: 05

YEAR: 2007

Characterization of the immunoglobulin A heavy chain gene of the Atlantic bottlenose dolphin (Tursiops truncatus). Information

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LANGUAGE: eng

NlmUniqueID: 8002006

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Grant and Affiliation Information for Characterization of the immunoglobulin A heavy chain gene of the Atlantic bottlenose dolphin (Tursiops truncatus).

AFFILIATION: Marine Biomedicine and Environmental Science Center, Medical University of South Carolina, Charleston, SC 29412, USA. mancia@musc.edu

Country: Netherlands

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MEDLINETA: Vet Immunol Immunopathol

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