Characterization of the Epstein-Barr virus glycoprotein BMRF-2.

Characterization of the Epstein-Barr virus glycoprotein BMRF-2. Research Abstract Details 

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Characterization of the Epstein-Barr virus glycoprotein BMRF-2. Abstract Text:

Jianqiao Xiao,Joel M Palefsky,Rossana Herrera,Sharof M Tugizov,

Epstein-Barr virus (EBV) BMRF-2 protein interaction with the beta1 family of integrins plays an important role in EBV infection of polarized oral epithelial cells. In this work, we characterized BMRF-2 protein expression in EBV-infected B lymphoblastoid and polarized oral epithelial cells, and in hairy leukoplakia (HL) epithelium. BMRF-2 expression in B cells and polarized oral epithelial cells was associated with the EBV lytic infection. In these cells, BMRF-2 is efficiently transported to the cell membrane and its integrin binding Arg-Gly-Asp (RGD) motif is exposed on the cell surface. BMRF-2 is highly expressed in HL epithelium and accumulates at the lateral border of oral keratinocytes. In EBV-infected polarized oral epithelial cells, this protein is transported to the basolateral membranes and co-localized with beta1 integrin. These data suggest that BMRF-2 may play an important role in cell-to-cell spread of EBV within the oral epithelium. BMRF-2 is glycosylated through O-linked oligosaccharides; it forms oligomers and is associated with the virion envelope. Its C-terminal tail is localized in the cytoplasm. We found that beta1, alpha5, and alpha3 integrins are present in purified EBV virions. We show that BMRF-2 is a ligand for beta1, alpha5, alpha3, and alphav integrins and our data are consistent with a role for BMRF-2 in viral lytic infection.

Characterization of the Epstein-Barr virus glycoprotein BMRF-2. Publishing Authors By Initials

J Xiao,JM Palefsky,R Herrera,SM Tugizov,

For similar proteins: viral proteins research abstracts see: proteins: viral proteins research

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Characterization of the Epstein-Barr virus glycoprotein BMRF-2. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Virology

VOLUME: 359

Page Numbers: 382-96

Journal Abbreviation: Virology

ISSN: 0042-6822

DAY: 1

MONTH: 11

YEAR: 2006

Characterization of the Epstein-Barr virus glycoprotein BMRF-2. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 110674

Characterization of the Epstein-Barr virus glycoprotein BMRF-2. Keywords Mesh Terms:

KEYWORDS: Viral Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: Characterization of the Epstein-Barr virus glycoprotein BMRF-2. Information

Substance Name: Viral Proteins

Registry Number: 0

Grant and Affiliation Information for Characterization of the Epstein-Barr virus glycoprotein BMRF-2.

AFFILIATION: Department of Medicine, University of California, San Francisco, USA.

Country: United States

AGENCY: United States NIDCR

GRANT: R21 DE016009

ACRONYM: DE

MEDLINETA: Virology

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