Characterization of the cytoplasmic inclusion bodies of the spleens from patients with adult form Gaucher's disease.

Characterization of the cytoplasmic inclusion bodies of the spleens from patients with adult form Gaucher's disease. Research Abstract Details 

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Characterization of the cytoplasmic inclusion bodies of the spleens from patients with adult form Gaucher's disease. Abstract Text:

H Ebato,T Abe,T Yamakawa,K Nagashima,

The twisted tubular cytoplasmic inclusion bodies were isolated from spleens of four patients with adult form Gaucher's disease. The chemical composition of the CIB (cytoplasmic inclusion bodies) was as follows: proteins, 10%, cholesterol, 10%, phospholipids, 10%, glycolipids, 70%. More than 90% of glycolipids from CIB were glucosylceramide. The structural protein profile of these bodies was examined by SDS-polyacrylamide disc gel electrophoresis on a semimicro-scale (s-PAGE). A similar protein composition which included two glycoproteins was found in all the four cases. The tubular structure of the bodies was changed to a small and round form by the treatment with 1 mM EDTA-Na2 which removed some structural proteins from the bodies. This indicated that some proteins might have an important role in maintaining the tubular structure of CIB.

Characterization of the cytoplasmic inclusion bodies of the spleens from patients with adult form Gaucher's disease. Publishing Authors By Initials

H Ebato,T Abe,T Yamakawa,K Nagashima,

For similar tissues: lymphoid tissue: spleen research abstracts see: tissues: lymphoid tissue: spleen research

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Characterization of the cytoplasmic inclusion bodies of the spleens from patients with adult form Gaucher's disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 88

Page Numbers: 1765-72

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Dec

YEAR: 1980

Characterization of the cytoplasmic inclusion bodies of the spleens from patients with adult form Gaucher's disease. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Characterization of the cytoplasmic inclusion bodies of the spleens from patients with adult form Gaucher's disease. Keywords Mesh Terms:

KEYWORDS: Spleen

MESH TERMS: ultrastructure

Chemical & Substance for Abstract: Characterization of the cytoplasmic inclusion bodies of the spleens from patients with adult form Gaucher's disease. Information

Substance Name: Edetic Acid

Registry Number: 60-00-4

Grant and Affiliation Information for Characterization of the cytoplasmic inclusion bodies of the spleens from patients with adult form Gaucher's disease.

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Country: JAPAN

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MEDLINETA: J Biochem

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