Characterization of tableting using the OSDRC system.

Characterization of tableting using the OSDRC system. Research Abstract Details 

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Characterization of tableting using the OSDRC system. Abstract Text:

Kazuyuki Shimizu,Masaki Ando,Yukiharu Nakayama,

PURPOSE: We compared the compression properties and characteristics of tablets obtained using the OSDRC system (method (OSDRC)) and conventional compression methods including multi-layer compression with a pharmaceutical powder. MATERIALS AND METHODS: We prepared tablets using four methods of compression. The force profiles, ejection force, stress relaxation, pressure transmission ratio, and internal intensity of the tablets were measured as compression properties. RESULTS: Method (OSDRC) gave the highest value for the crushing strength of the tablets. Although the compression properties were similar regardless of the method of compression, the internal intensity of tablets compressed by method (OSDRC) was significantly larger than that of the tablets produced by the other methods. CONCLUSIONS: In terms of crushing strength, the tablets compressed by method (OSDRC) were superior of those obtained by the conventional compression method. Therefore, it is possible to increase the crushing strength of tablets without changing the pharmaceutical formulation.

Characterization of tableting using the OSDRC system. Publishing Authors By Initials

K Shimizu,M Ando,Y Nakayama,

For similar investigative techniques: technology, pharmaceutical research abstracts see: investigative techniques: technology, pharmaceutical research

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Characterization of tableting using the OSDRC system. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Pharmaceutical research

VOLUME: 24

Page Numbers: 1902-9

Journal Abbreviation: Pharm. Res.

ISSN: 0724-8741

DAY: 8

MONTH: 06

YEAR: 2007

Characterization of tableting using the OSDRC system. Information

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LANGUAGE: eng

NlmUniqueID: 8406521

Characterization of tableting using the OSDRC system. Keywords Mesh Terms:

KEYWORDS: Technology, Pharmaceutical

MESH TERMS: methods

Chemical & Substance for Abstract: Characterization of tableting using the OSDRC system. Information

Substance Name: hydroxypropylcellulose

Registry Number: 9004-64-2

Grant and Affiliation Information for Characterization of tableting using the OSDRC system.

AFFILIATION: Pharmaceutical Research & Technology Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd., 363 Shiosaki Hokusei, Inabe Mie, 511-0406, Japan. ka_shimizu@skk-net.com

Country: United States

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MEDLINETA: Pharm Res

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