Characterization of shock in a hamster model of hantavirus infection.

Characterization of shock in a hamster model of hantavirus infection. Research Abstract Details 

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Characterization of shock in a hamster model of hantavirus infection. Abstract Text:

Matthew J Campen,Mary Louise Milazzo,Charles F Fulhorst,Chrys J Obot Akata,Frederick Koster,

Human hantavirus cardiopulmonary syndrome (HCPS) due to Andes, sin nombre and other hantaviruses is characterized by severe pulmonary capillary leak and cardiogenic shock. Hamsters, the only animal manifesting HCPS-like disease, were instrumented with radiotelemeters that enabled ambulatory intracarotid blood pressure recording within an animal biosafety level-4 facility. Following infection with Andes virus, blood pressure and heart rate decreased slowly in a biphasic manner during the first 7 days of infection, followed by a rapid fall in pressure and rapid increase in heart rate during the 10-20 h preceding death on day 9 or 10. The preterminal narrowing of pulse pressure was consistent with a cardiogenic impairment. Heart rate variability analysis implicated increased sympathetic nervous system activity as seen in human HCPS. The hamster model of HCPS mimics not only the pulmonary capillary leak but also the hypotension characteristic of human HCPS.

Characterization of shock in a hamster model of hantavirus infection. Publishing Authors By Initials

MJ Campen,ML Milazzo,CF Fulhorst,CJ Obot Akata,F Koster,

For similar diagnosis: diagnostic techniques and procedures: monitoring, physiologic: telemetry research abstracts see: diagnosis: diagnostic techniques and procedures: monitoring, physiologic: telemetry research

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Characterization of shock in a hamster model of hantavirus infection. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Virology

VOLUME: 356

Page Numbers: 45-9

Journal Abbreviation: Virology

ISSN: 0042-6822

DAY: 6

MONTH: 09

YEAR: 2006

Characterization of shock in a hamster model of hantavirus infection. Information

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LANGUAGE: eng

NlmUniqueID: 110674

Characterization of shock in a hamster model of hantavirus infection. Keywords Mesh Terms:

KEYWORDS: Telemetry

MESH TERMS: methods

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Grant and Affiliation Information for Characterization of shock in a hamster model of hantavirus infection.

AFFILIATION: Pathophysiology Division, Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108, USA.

Country: United States

AGENCY: United States PHS

GRANT: U54-AL-057156

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MEDLINETA: Virology

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