Characterization of Salmonella enterica serovar Typhimurium DT104 invasion in an epithelial cell line (IPEC J2) from porcine small intestine.

Characterization of Salmonella enterica serovar Typhimurium DT104 invasion in an epithelial cell line (IPEC J2) from porcine small intestine. Research Abstract Details 

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Characterization of Salmonella enterica serovar Typhimurium DT104 invasion in an epithelial cell line (IPEC J2) from porcine small intestine. Abstract Text:

David R Brown,Lisa D Price,

Salmonella Typhimurium DT104 is an emerging enteric pathogen in swine of increasing medical importance. In this study, the time course and the actin-dependent host signaling processes necessary for invasion of a S. Typhimurium DT104 field isolate were investigated in IPEC J2 epithelial cells derived from porcine small intestine. Internalized bacteria were quantified by a gentamicin resistance assay. DT104 internalization into epithelial monolayers increased steadily between 15 and 120min after apical inoculation. Internalization was reduced by the Rho GTPase inhibitor mevastatin, the N-WASP inhibitor wiskostatin and the actin-disrupting agent cytochalasin D, but not the Rac1 GTPase inhibitor NSC-23766. Early DT104 invasion of porcine enterocytes appears to be mediated by Rac1 GTPase-independent changes in epithelial actin assembly.

Characterization of Salmonella enterica serovar Typhimurium DT104 invasion in an epithelial cell line (IPEC J2) from porcine small intestine. Publishing Authors By Initials

DR Brown,LD Price,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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Characterization of Salmonella enterica serovar Typhimurium DT104 invasion in an epithelial cell line (IPEC J2) from porcine small intestine. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Veterinary microbiology

VOLUME: 120

Page Numbers: 328-33

Journal Abbreviation: Vet. Microbiol.

ISSN: 0378-1135

DAY: 8

MONTH: 12

YEAR: 2006

Characterization of Salmonella enterica serovar Typhimurium DT104 invasion in an epithelial cell line (IPEC J2) from porcine small intestine. Information

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LANGUAGE: eng

NlmUniqueID: 7705469

Characterization of Salmonella enterica serovar Typhimurium DT104 invasion in an epithelial cell line (IPEC J2) from porcine small intestine. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: microbiology

Chemical & Substance for Abstract: Characterization of Salmonella enterica serovar Typhimurium DT104 invasion in an epithelial cell line (IPEC J2) from porcine small intestine. Information

Substance Name: Lovastatin

Registry Number: 75330-75-5

Grant and Affiliation Information for Characterization of Salmonella enterica serovar Typhimurium DT104 invasion in an epithelial cell line (IPEC J2) from porcine small intestine.

AFFILIATION: Department of Veterinary and Biomedical Sciences, University of Minnesota, St Paul, MN 55108-6010, USA. brown013@umn.edu

Country: Netherlands

AGENCY: United States NIDA

GRANT: R01 DA010200-10

ACRONYM: DA

MEDLINETA: Vet Microbiol

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