Characterization of phenolic compounds in the crude extract of Hedysarum multijugum by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry.

Characterization of phenolic compounds in the crude extract of Hedysarum multijugum by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. Research Abstract Details 

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Characterization of phenolic compounds in the crude extract of Hedysarum multijugum by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. Abstract Text:

Min Yang,Wei Wang,Jianghao Sun,Yuying Zhao,Yi Liu,Hong Liang,De-An Guo,Min Yang,Wei Wang,Jianghao Sun,Yuying Zhao,Yi Liu,Hong Liang,De-an Guo,Min Yang,Wei Wang,Jianghao Sun,Yuying Zhao,Yi Liu,Hong Liang,De-an Guo,

The fragmentation behavior of four types of phenolic compounds: coumestans, pterocarpenes, benzofurans and isoflavones, were studied using electrospray ionization multistage mass spectrometry (ESI-MS(n)) (n = 2-5) in negative ion mode. Losses of methyl (15 Da), CO (28 Da), CO(2) (44 Da), isopropyl (43 Da) and isobutenyl (55 Da) were dominating fragmentation patterns. Different positions and numbers of the substituents also led to the different fragmentation behavior. These fragmentation rules were applied for the identification of constituents in methanolic extracts of Hedysarum multijugum, in which 29 compounds were characterized, including nine new compounds. The method established in this study could be applied to the comprehensive quality control of the herb and its formulations. It could also be applied to the biological and pharmacological research of traditional Chinese medicines. Copyright (c) 2007 John Wiley & Sons, Ltd.

Characterization of phenolic compounds in the crude extract of Hedysarum multijugum by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. Publishing Authors By Initials

M Yang,W Wang,J Sun,Y Zhao,Y Liu,H Liang,DA Guo,M Yang,W Wang,J Sun,Y Zhao,Y Liu,H Liang,DA Guo,M Yang,W Wang,J Sun,Y Zhao,Y Liu,H Liang,DA Guo,

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Characterization of phenolic compounds in the crude extract of Hedysarum multijugum by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Rapid communications in mass spectrometry : RCM

VOLUME: 21

Page Numbers: 3833-41

Journal Abbreviation: Rapid Commun. Mass Spectrom.

ISSN: 0951-4198

DAY: 16

MONTH: 11

YEAR: 2007

Characterization of phenolic compounds in the crude extract of Hedysarum multijugum by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry. Information

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LANGUAGE: eng

NlmUniqueID: 8802365

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Grant and Affiliation Information for Characterization of phenolic compounds in the crude extract of Hedysarum multijugum by high-performance liquid chromatography with electrospray ionization tandem mass spectrometry.

AFFILIATION: The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, P.R. China.

Country: England

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MEDLINETA: Rapid Commun Mass Spectrom

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