Characterization of NAD Uptake in Mammalian Cells.

Characterization of NAD Uptake in Mammalian Cells. Research Abstract Details 

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Characterization of NAD Uptake in Mammalian Cells. Abstract Text:

Richard A Billington,Cristina Travelli,Emanuela Ercolano,Ubaldina Galli,Cintia Blasi Roman,Ambra A Grolla,Pier Luigi Canonico,Fabrizio Condorelli,Armando A Genazzani,

Recent evidence has shown that NAD(P) plays a variety of roles in cell-signaling processes. Surprisingly, the presence of NAD(P) utilizing ectoenzymes suggests that NAD(P) is present extracellularly. Indeed, nanomolar concentrations of NAD have been found in plasma and other body fluids. Although very high concentrations of NAD have been shown to enter cells, it is not known whether lower, more physiological concentrations are able to be taken up. Here we show that two mammalian cell types are able to transport low NAD concentrations effectively. Furthermore, extracellular application of NAD was able to counteract FK866-induced cell death and restore intracellular NAD(P) levels. We propose that NAD uptake may play a role in physiological NAD homeostasis.

Characterization of NAD Uptake in Mammalian Cells. Publishing Authors By Initials

RA Billington,C Travelli,E Ercolano,U Galli,CB Roman,AA Grolla,PL Canonico,F Condorelli,AA Genazzani,

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Characterization of NAD Uptake in Mammalian Cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Journal of biological chemistry

VOLUME: 283

Page Numbers: 6367-74

Journal Abbreviation: J. Biol. Chem.

ISSN: 0021-9258

DAY: 7

MONTH: 01

YEAR: 2008

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LANGUAGE: eng

NlmUniqueID: 2985121

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AFFILIATION: Dipartimento di Scienze Chimiche, Alimentari, Farmaceutiche e Farmacologiche and the Drug and Food Biotechnology Center, Università del Piemonte Orientale, Via Bovio 6, Novara 28100, Italy.

Country: United States

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MEDLINETA: J Biol Chem

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