Characterization of mucins in human middle ear and Eustachian tube.

Characterization of mucins in human middle ear and Eustachian tube. Research Abstract Details 

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Characterization of mucins in human middle ear and Eustachian tube. Abstract Text:

J Lin,V Tsuprun,H Kawano,M M Paparella,Z Zhang,R Anway,S B Ho,

Mucins are important glycoproteins in the mucociliary transport system of the middle ear and Eustachian tube. Little is known about mucin expression within this system under physiological and pathological conditions. This study demonstrated the expression of MUC5B, MUC5AC, MUC4, and MUC1 in the human Eustachian tube, whereas only MUC5B mucin expression was demonstrated in noninflamed middle ears. MUC5B and MUC4 mucin genes were upregulated 4.2- and 6-fold, respectively, in middle ears with chronic otitis media (COM) or mucoid otitis media (MOM). This upregulation of mucin genes was accompanied by an increase of MUC5B- and MUC4-producing cells in the middle ear mucosa. Electron microscopy of the secretions from COM and MOM showed the presence of chainlike polymeric mucin. These data indicate that the epithelium of the middle ear and Eustachian tube expresses distinct mucin profiles and that MUC5B and MUC4 mucins are highly produced and secreted in the diseased middle ear. These mucins may form thick mucous effusion in the middle ear cavity and compromise the function of the middle ear.

Characterization of mucins in human middle ear and Eustachian tube. Publishing Authors By Initials

J Lin,V Tsuprun,H Kawano,MM Paparella,Z Zhang,R Anway,SB Ho,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

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Characterization of mucins in human middle ear and Eustachian tube. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: American journal of physiology. Lung cellular and

VOLUME: 280

Page Numbers: L1157-67

Journal Abbreviation: Am. J. Physiol. Lung Cell Mol.

ISSN: 1040-0605

DAY: 1

MONTH: Jun

YEAR: 2001

Characterization of mucins in human middle ear and Eustachian tube. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901229

Characterization of mucins in human middle ear and Eustachian tube. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Characterization of mucins in human middle ear and Eustachian tube. Information

Substance Name: mucin 5AC

Registry Number: 0

Grant and Affiliation Information for Characterization of mucins in human middle ear and Eustachian tube.

AFFILIATION: Department of Otolaryngology, University of Minnesota School of Medicine, Minneapolis, MN 55455, USA. linxx004@tc.umn.edu

Country: United States

AGENCY: United States NIDCD

GRANT: R01-DC-03433

ACRONYM: DC

MEDLINETA: Am J Physiol Lung Cell Mol Phy

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