Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1.

Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1. Research Abstract Details 

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Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1. Abstract Text:

S Harumiya,K Takeda,T Sugiura,Y Fukumoto,H Tachikawa,K Miyazono,D Fujimoto,H Ichijo,

A novel elastin-binding protein, EBP-37, was recently identified and purified from human plasma. Its partial amino acid sequences showed significant homology to porcine ficolins, which were originally purified from porcine uterus membranes as multimeric proteins with fibrinogen- and collagen-like domains. Here we report the presence of ficolins in an elastin-binding fraction of porcine plasma and the direct binding of recombinant porcine ficolin-alpha to elastin. In addition, a cDNA encoding a human counterpart of porcine ficolins that is composed of 319 amino acids and is different from EBP-37 was cloned and named human ficolin-1. Northern blotting of various human tissues revealed that human ficolin-1 mRNA is highly expressed in peripheral blood leukocytes. These data suggested that there are at least two kinds of ficolin-related proteins in both pig and human, and they may function as plasma proteins with elastin-binding activities.

Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1. Publishing Authors By Initials

S Harumiya,K Takeda,T Sugiura,Y Fukumoto,H Tachikawa,K Miyazono,D Fujimoto,H Ichijo,

For similar animals: chordata: vertebrates: mammals: artiodactyla: swine research abstracts see: animals: chordata: vertebrates: mammals: artiodactyla: swine research

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Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 120

Page Numbers: 745-51

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Oct

YEAR: 1996

Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1. Keywords Mesh Terms:

KEYWORDS: Swine

MESH TERMS: chemistry

Chemical & Substance for Abstract: Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1. Information

Substance Name: Elastin

Registry Number: 9007-58-3

Grant and Affiliation Information for Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1.

AFFILIATION: Department of Biochemistry, Cancer Institute, Tokyo, Japanese Foundation for Cancer Research.

Country: JAPAN

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MEDLINETA: J Biochem

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ACCESSION NUMBER: D83920

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