Characterization of clozapine-induced changes in synaptic plasticity in the hippocampal-mPFC pathway of anesthetized rats.

Characterization of clozapine-induced changes in synaptic plasticity in the hippocampal-mPFC pathway of anesthetized rats. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Characterization of clozapine-induced changes in synaptic plasticity in the hippocampal-mPFC pathway of anesthetized rats. Abstract Text:

Machiko Matsumoto,Hiroki Shikanai,Hiroko Togashi,Takeshi Izumi,Takeya Kitta,Riki Hirata,Taku Yamaguchi,Mitsuhiro Yoshioka,

Synaptic plasticity expressed as long-term potentiation (LTP) in the hippocampal-medial prefrontal cortex (mPFC) pathway is considered to be involved in cognitive function and learning and memory processes, but its synaptic mechanism remains unknown. The present study characterized LTP in the mPFC using the atypical antipsychotic clozapine, with a focus on dopaminergic modulation. The magnitude of LTP was facilitated by pretreatment with clozapine (20 mg/kg, i.p.), but not by the typical antipsychotic haloperidol (1 mg/kg, i.p.). Clozapine-induced LTP augmentation was blocked by the dopamine D(1) receptor antagonist SCH-23390 (10 mug/rat, i.c.v.), but not by the D(2) receptor antagonist remoxipride (10 mug/rat, i.c.v.) or the 5-HT(1A) receptor antagonist WAY-100635 (20 mug/rat, i.c.v.). SCH-23390 (10 mug/rat, i.c.v.) by itself did not affect LTP induction. The D(1) receptor agonist SKF-38393 (10 mug/kg, i.c.v.) facilitated LTP, mimicking the clozapine-induced response. Furthermore, in vivo microdialysis showed that transient increases in mPFC dopamine levels induced by tetanic stimulation sustained facilitation following clozapine administration (20 mg/kg, i.p.). These results demonstrate the importance of the D(1) receptor as a mediator of clozapine-induced LTP augmentation through enhanced dopaminergic activity. Augmentation of synaptic plasticity in the hippocampal-mPFC pathway via D(1) receptors appears to be responsible for the therapeutic effects of clozapine.

Characterization of clozapine-induced changes in synaptic plasticity in the hippocampal-mPFC pathway of anesthetized rats. Publishing Authors By Initials

M Matsumoto,H Shikanai,H Togashi,T Izumi,T Kitta,R Hirata,T Yamaguchi,M Yoshioka,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Characterization of clozapine-induced changes in synaptic plasticity in the hippocampal-mPFC pathway of anesthetized rats. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Brain research

VOLUME: 1195

Page Numbers: 50-5

Journal Abbreviation: Brain Res.

ISSN: 0006-8993

DAY: 14

MONTH: 12

YEAR: 2007

Characterization of clozapine-induced changes in synaptic plasticity in the hippocampal-mPFC pathway of anesthetized rats. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 45503

Characterization of clozapine-induced changes in synaptic plasticity in the hippocampal-mPFC pathway of anesthetized rats. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Characterization of clozapine-induced changes in synaptic plasticity in the hippocampal-mPFC pathway of anesthetized rats. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Characterization of clozapine-induced changes in synaptic plasticity in the hippocampal-mPFC pathway of anesthetized rats.

AFFILIATION: Department of Pharmacological Sciences, School of Pharmaceutical Science, Health Sciences University of Hokkaido, Ishikari-Tobetsu, 060-0293 Japan; Department of Neuropharmacology, Hokkaido University Graduate School of Medicine, Sapporo, 060-8638 Japan.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Brain Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Characterization of clozapine-induced changes in synaptic plasticity in the hippocampal-mPFC pathway of anesthetized rats Related Publications

• An Improved Chemo-Enzymatic Synthesis of 1-beta-O-Acyl Glucuronides: Highly Chemoselective Enzymatic Removal of Protecting Groups from Corresponding Methyl Acetyl Derivatives.
• Anatomic identification and functional outcomes of the nerve sparing Okabayashi radical hysterectomy.
• Association between heat stress protein 70 induction and decreased pulmonary fibrosis in an animal model of acute lung injury.
• Characterization of clozapine-induced changes in synaptic plasticity in the hippocampal-mPFC pathway of anesthetized rats.
• Di(triptycyl)carbene: a fairly persistent triplet dialkylcarbene.
• Dynamic sonography of hepatic tumors.
• Early postnatal stress affects the serotonergic function in the median raphe nuclei of adult rats.
• Factor V C2 domain contains a major thrombin-binding site responsible for thrombin-catalyzed factor V activation.
• Functional imaging of shear-dependent activity of ADAMTS13 in regulating mural thrombus growth under whole blood flow conditions.
• Heat stress facilitates stretch-induced hypertrophy of cultured muscle cells.
• Indication and limitations of using palatal rugae for personal identification in edentulous cases.
• Mechanism of asymmetric ovarian development in chick embryos.
• Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death.
• Neuroendoscopic approach to tectal tumors: a consecutive series.
• Nucleotide sugar transporters: elucidation of their molecular identity and its implication for future studies.
• On a phosphoprotein isolated from trout egg.
• Phosvitin of the trout roe.
• Recent advance in the treatment of hilar cholangiocarcinoma: hepatectomy with vascular resection.
• Reversible redox behavior between stannole dianion and bistannole-1,2-dianion.
• Scaffold proteins in mammalian MAP kinase cascades.
• Stability of the Mycoplasma synoviae hemagglutinating antigen against refrigeration, freezing and lyophilization.
• Studies of electrolytes metabolism in serum and after cardiac surgery especially changes in total and ionized calcium (author's transl)]
• The 30 kDa abnormal protein in avian dystrophic muscle is indistinguishable from carbonic anhydrase III by physicochemical, immunological, and enzymological criteria.
• The chimeric cyclic nucleotide-gated ion channel ATCNGC11/12 constitutively induces programmed cell death in a Ca(2+) dependent manner.
• [Aortic valve replacement of a patient with hemophilia A]
• [Experimental and clinical studies on the relationship between 3-methoxy 4-hydroxymandelic acid (VMA) levels and the thyroid function. I. Influence of thyroid function upon urinary VMA levels.]
• [Standardized treatment of acute intoxication--present state in Japan]
• [Surgical repair of atrial septal defects with absence of right superior vena cava and persistent left superior vena cava]
• [Therapeutic effectiveness of trichomycin in experimental keratomycosis and immunological considerations.]
• [Viewpoint of young physicians aiming to become pediatric psychiatrists]