Characterization of blackberry extract and its antiproliferative and anti-inflammatory properties.

Characterization of blackberry extract and its antiproliferative and anti-inflammatory properties. Research Abstract Details 

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Characterization of blackberry extract and its antiproliferative and anti-inflammatory properties. Abstract Text:

Jin Dai,Jigna D Patel,Russell J Mumper,

Blackberries are rich in polyphenols, including anthocyanins. Polyphenols are hypothesized to have biological activities that may impact positively on human health. In these studies, an anthocyanin-rich extract from Hull blackberries grown in Kentucky was obtained and fully characterized in terms of total anthocyanin and phenolic content, polymeric color, anthocyanin composition, and total antioxidant capacity. In vitro cell culture studies showed that the blackberry extract inhibited HT-29 colon tumor cell growth in a concentration-dependent manner with 49.2 microg of total anthocyanins/mL inhibiting HT-29 cell growth up to 66% at 72 hours. Likewise, in a concentration-dependent manner, total anthocyanin concentrations in the range of 0-40 microg/mL suppressed both high-dose (10 microg/mL) and low-dose (0.1 microg/mL) lipid A-induced interleukin-12 release from mouse bone marrow-derived dendritic cells. These results suggest that Hull blackberry extract (HBE) has potent antioxidant, antiproliferative, and anti-inflammatory activities and that HBE-formulated products may have the potential for the treatment and/or prevention of cancer and/or other inflammatory diseases.

Characterization of blackberry extract and its antiproliferative and anti-inflammatory properties. Publishing Authors By Initials

J Dai,JD Patel,RJ Mumper,

For similar plants: plant families and groups: angiosperms: rosales: rosaceae research abstracts see: plants: plant families and groups: angiosperms: rosales: rosaceae research

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Characterization of blackberry extract and its antiproliferative and anti-inflammatory properties. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of medicinal food

VOLUME: 10

Page Numbers: 258-65

Journal Abbreviation:

ISSN: 1096-620X

DAY: 26

MONTH: Jun

YEAR: 2007

Characterization of blackberry extract and its antiproliferative and anti-inflammatory properties. Information

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LANGUAGE: eng

NlmUniqueID: 9812512

Characterization of blackberry extract and its antiproliferative and anti-inflammatory properties. Keywords Mesh Terms:

KEYWORDS: Rosaceae

MESH TERMS: chemistry

Chemical & Substance for Abstract: Characterization of blackberry extract and its antiproliferative and anti-inflammatory properties. Information

Substance Name: Interleukin-12

Registry Number: 187348-17-0

Grant and Affiliation Information for Characterization of blackberry extract and its antiproliferative and anti-inflammatory properties.

AFFILIATION: Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, Kentucky, USA.

Country: United States

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MEDLINETA: J Med Food

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