Characterization of apolipoprotein A-V structure and mode of plasma triacylglycerol regulation.

Characterization of apolipoprotein A-V structure and mode of plasma triacylglycerol regulation. Research Abstract Details 

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Characterization of apolipoprotein A-V structure and mode of plasma triacylglycerol regulation. Abstract Text:

Kasuen Wong,Robert O Ryan,

PURPOSE OF REVIEW: Cardiovascular disease is the leading cause of death in the USA, and hypertriglyceridemia represents an independent risk factor contributing to its premature onset. Apolipoprotein (apo)A-V has been shown to be a potent regulator of plasma triacylglycerol. We highlight structural aspects of apoA-V and discuss recent findings that provide mechanistic insight into its function as a regulator of plasma triacylglycerol metabolism. RECENT FINDINGS: Recent findings indicate that apoA-V is comprised of two independently folded domains. Fluorescence spectroscopy and truncation analysis revealed that the carboxyl-terminal region functions in apoA-V lipid binding, consistent with its known association with plasma lipoproteins. An indirect triacylglycerol-modulating effect of apoA-V has been attributed to heparan sulfate proteoglycan binding, as confirmed by structural studies. Furthermore, apoA-V has been shown to interact with cell surface receptors, potentially facilitating lipoprotein particle endocytosis. SUMMARY: Several features of apoA-V, including extremely low plasma concentration, lack of correlation with plasma cholesterol levels despite its association with HDL, and insolubility at neutral pH in the absence of lipid, are unlike those of other exchangeable apolipoproteins. Current and future studies of apoA-V will help to shed light on the molecular basis whereby this protein functions to modulate plasma lipid homeostasis.

Characterization of apolipoprotein A-V structure and mode of plasma triacylglycerol regulation. Publishing Authors By Initials

K Wong,RO Ryan,

For similar lipids: glycerides: triglycerides research abstracts see: lipids: glycerides: triglycerides research

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Characterization of apolipoprotein A-V structure and mode of plasma triacylglycerol regulation. Journal Published:

PUBLICATION TYPE: Review

Journal: Current opinion in lipidology

VOLUME: 18

Page Numbers: 319-24

Journal Abbreviation: Curr. Opin. Lipidol.

ISSN: 0957-9672

DAY: 3

MONTH: Jun

YEAR: 2007

Characterization of apolipoprotein A-V structure and mode of plasma triacylglycerol regulation. Information

Number of References: 40

LANGUAGE: eng

NlmUniqueID: 9010000

Characterization of apolipoprotein A-V structure and mode of plasma triacylglycerol regulation. Keywords Mesh Terms:

KEYWORDS: Triglycerides

MESH TERMS: metabolism

Chemical & Substance for Abstract: Characterization of apolipoprotein A-V structure and mode of plasma triacylglycerol regulation. Information

Substance Name: Triglycerides

Registry Number: 0

Grant and Affiliation Information for Characterization of apolipoprotein A-V structure and mode of plasma triacylglycerol regulation.

AFFILIATION: Center for Prevention of Obesity, Diabetes and Cardiovascular Disease, Children's Hospital Oakland Research Institute, Oakland, California 94609, USA.

Country: England

AGENCY: United States NHLBI

GRANT: HL 073061

ACRONYM: HL

MEDLINETA: Curr Opin Lipidol

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