Characterization of alterations of hemodynamics and neuroendocrine hormones in dexamethasone induced hypertension in dogs.

Characterization of alterations of hemodynamics and neuroendocrine hormones in dexamethasone induced hypertension in dogs. Research Abstract Details 

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Characterization of alterations of hemodynamics and neuroendocrine hormones in dexamethasone induced hypertension in dogs. Abstract Text:

H Nakamoto,H Suzuki,Y Kageyama,A Ohishi,M Murakami,M Naitoh,T Saruta,

The serial changes in systemic and renal hemodynamics, water and electrolyte balances and various vasoactive hormones were examined in 12 conscious dogs before, during (10 days) the administration of dexamethasone (DEX: 0.5 mg/kg/day) and after the cessation of DEX. In addition, during the administration of DEX, pressor responses to angiotensin II, norepinephrine, an angiotensin II analogue, saralasin, and an alpha-1-blocker, prazosin, were studied. Abrupt elevation of blood pressure to 106 +/- 5 mmHg on Day 1 (vs. 91 +/- 6 mmHg control: P less than 0.05) associated with marked increases in total peripheral resistance (P less than 0.01) was shown in DEX treated animals. Accompanied with these changes, renal blood flow increased to 146 +/- 12 ml/min (vs. 103 +/- 8 ml/min control: P less than 0.05) on Day 1 and maintained. In contrast, the results of serial alterations in hormones could not show any significant changes except significant elevations in atrial natriuretic peptide and reductions of cortisol and arginine vasopressin. Also, marked natriuresis and diuresis were observed in DEX administration dogs. Pressor response to norepinephrine was significantly increased and administration of either saralasin and prazosin significantly reduced the blood pressure of DEX treated animals. These results in DEX-treated conscious dogs confirmed our previous findings in human and rats. Glucocorticoid-induced hypertension mainly depends on the increases in total peripheral resistance but not volume factors.

Characterization of alterations of hemodynamics and neuroendocrine hormones in dexamethasone induced hypertension in dogs. Publishing Authors By Initials

H Nakamoto,H Suzuki,Y Kageyama,A Ohishi,M Murakami,M Naitoh,T Saruta,

For similar circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic phenomena: hemodynamics: vascular resistance research abstracts see: circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic phenomena: hemodynamics: vascular resistance research

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Characterization of alterations of hemodynamics and neuroendocrine hormones in dexamethasone induced hypertension in dogs. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 13

Page Numbers: 587-606

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1991

Characterization of alterations of hemodynamics and neuroendocrine hormones in dexamethasone induced hypertension in dogs. Information

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LANGUAGE: eng

NlmUniqueID: 8207790

Characterization of alterations of hemodynamics and neuroendocrine hormones in dexamethasone induced hypertension in dogs. Keywords Mesh Terms:

KEYWORDS: Vascular Resistance

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Characterization of alterations of hemodynamics and neuroendocrine hormones in dexamethasone induced hypertension in dogs. Information

Substance Name: Norepinephrine

Registry Number: 51-41-2

Grant and Affiliation Information for Characterization of alterations of hemodynamics and neuroendocrine hormones in dexamethasone induced hypertension in dogs.

AFFILIATION: Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.

Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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