Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis.

Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis. Research Abstract Details 

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Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis. Abstract Text:

Lingling Liu,Jianxuan Zhang,Jian Yuan,Yongjun Dang,Chenyi Yang,Xiujuan Chen,Jianing Xu,Long Yu,

Protein phosphatase 3 (PPP3, formerly PP2B, Calcineurin), a serine/threonine protein phosphatase, is a heterodimer composed of one catalytic subunit (PPP3C, Calcineurin A) and one regulatory subunit (PPP3R, Calcineurin B). PPP3R, an EF-hand Ca2+ binding protein, contains four high-affinity EF-hand calcium-binding sites, indicating that PPP3 plays critical roles in many calcium-mediated signal transduction pathways. PPP3R has two isoforms, PPP3R1 (also known as PP2Bbeta1) and PPP3R2 (also known as PP2BB2). While PPP3R1 is ubiquitously expressed in different tissues, PPP3R2 is exclusively expressed in testis. PPP3R2 has only been identified in rat and mouse. Here we report a human homologue of PPP3R2, which is designated PPP3RL (PPP3R like protein). PPP3RL gene was predicated to encode 171 amino acid residues with four EF-hand calcium-binding domains and this putative protein shares 82.9% and 80.5% identity with PPP3R2 of rat and mouse, respectively. Our results show that PPP3RL gene localizes to human chromosome 9q22 and transcripts of PPP3RL gene are specifically expressed in the testis, moreover, this tissue-specific expression is due to demethylation of its promoter region in testis.

Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis. Publishing Authors By Initials

L Liu,J Zhang,J Yuan,Y Dang,C Yang,X Chen,J Xu,L Yu,

For similar genetic processes: gene expression: transcription, genetic research abstracts see: genetic processes: gene expression: transcription, genetic research

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Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Molecular biology reports

VOLUME: 32

Page Numbers: 41-5

Journal Abbreviation: Mol. Biol. Rep.

ISSN: 0301-4851

DAY: 12

MONTH: Mar

YEAR: 2005

Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis. Information

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LANGUAGE: eng

NlmUniqueID: 403234

Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis. Keywords Mesh Terms:

KEYWORDS: Transcription, Genetic

MESH TERMS: enzymology

Chemical & Substance for Abstract: Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis. Information

Substance Name: Phosphoprotein Phosphatases

Registry Number: EC 3.1.3.16

Grant and Affiliation Information for Characterization of a human regulatory subunit of protein phosphatase 3 gene (PPP3RL) expressed specifically in testis.

AFFILIATION: State Key Laboratory of Genetic Engineering of China, School of Life Science, Fudan University, 220 Handan Road, Shanghai 200433, the People's Republic of China.

Country: Netherlands

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MEDLINETA: Mol Biol Rep

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