Characterization of a group of essential hypertensives with impaired regulation of aldosterone.

Characterization of a group of essential hypertensives with impaired regulation of aldosterone. Research Abstract Details 

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Characterization of a group of essential hypertensives with impaired regulation of aldosterone. Abstract Text:

G Wambach,A Helber,G Bönner,A Konrads,W Hummerich,K A Meurer,W Kaufmann,

The pattern of aldosterone excretion during high sodium intake in 100 patients with essential hypertension allowed the differentiation of two groups: in the majority of patients (group A, n = 64) aldosterone excretion was suppressed below 6 micrograms/day similar to the normotensive control group. In a second group (group B, n = 36), aldosterone remained above the control range despite forced sodium loading. In group B, serum potassium was significantly lower than in patients of group A (3.81 +/- 0.44 meq/l vs. 4.26 +/- 0.57 meq/l, p less than 0.001). The blood pressure lowering effect of spironolactone (200 mg/d) was more pronounced among patients in group B. Plasma renin values tended to be lower in group B compared to patients with suppressed aldosterone. Infusion of Angiotensin II (0.1 - 2 micrograms/kg/min) led to a similar relative rise of plasma aldosterone levels in both groups despite higher baseline values in group B. The exact mechanism of the impaired regulation of aldosterone in a subgroup of patients with essential hypertension remains to be elucidated.

Characterization of a group of essential hypertensives with impaired regulation of aldosterone. Publishing Authors By Initials

G Wambach,A Helber,G Bönner,A Konrads,W Hummerich,KA Meurer,W Kaufmann,

For similar organic chemicals: lactones: spironolactone research abstracts see: organic chemicals: lactones: spironolactone research

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Characterization of a group of essential hypertensives with impaired regulation of aldosterone. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 4

Page Numbers: 1835-49

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1982

Characterization of a group of essential hypertensives with impaired regulation of aldosterone. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8207790

Characterization of a group of essential hypertensives with impaired regulation of aldosterone. Keywords Mesh Terms:

KEYWORDS: Spironolactone

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Characterization of a group of essential hypertensives with impaired regulation of aldosterone. Information

Substance Name: Renin

Registry Number: EC 3.4.23.15

Grant and Affiliation Information for Characterization of a group of essential hypertensives with impaired regulation of aldosterone.

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Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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