Characteristics of patients with Guillain Barre Syndrome at a tertiary care centre in Pakistan, 1995-2003.

Characteristics of patients with Guillain Barre Syndrome at a tertiary care centre in Pakistan, 1995-2003. Research Abstract Details 

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Characteristics of patients with Guillain Barre Syndrome at a tertiary care centre in Pakistan, 1995-2003. Abstract Text:

Mohammad Yawar Yakoob,Aisha Rahman,Bushra Jamil,Nadir Ali Syed,

OBJECTIVE: To study the clinical presentation, hospital course and outcome of patients admitted with Guillain Barre Syndrome (GBS) to a tertiary care hospital in Karachi, Pakistan. METHODS: The charts of patients conforming to International Classification of Diseases (ICD) code 9.0, for GBS, from September 1995 to January 2003 were reviewed. Clinical data was recorded on a standardized questionnaire, which included patients' age, sex, antecedent events, neurological signs and symptoms and ventilation requirement. The hospital course was analyzed, including nosocomial infections, therapy given and the functional status of patients, using the Rankin scale (0-6). Standard SPSS 11.5 software (Windows) was used for data analysis. RESULTS: Thirty-four cases of GBS were admitted to the hospital during the study period, with an age range of 3 to 70 years. The mean age for disease onset was 35.2 years for female patients, compared to 30 years for males; the male/female ratio was 1.6:1.Gastrointestinal infections (12/22, 54.6%) were the most common antecedent event, followed by upper respiratory tract infections (9/22, 40.9%) and skin lesions (1/22, 4.5%). Most patients developed GBS within one month of the preceding infection. Cranial nerve abnormalities (30/34, 88.2%), autonomic dysfunction (21/34, 61.8%) and respiratory failure requiring intubation (19/34, 55.9%) were also common. The median Rankin score of patients at admission, and at 30 and 60 days thereafter was 5, 4 and 3.5 respectively. The in-patient mortality was 1 of 34 (2.4%). CONCLUSION: We found that GBS occurred at all ages and was slightly more common in males. Majority of patients had an antecedent history of infection and had severe disease on presentation. The patients were treated with either plasmapheresis or intravenous immunoglobulins and there was no significant difference in outcome in the two groups. Despite severe persistent disability, in-hospital mortality was low.

Characteristics of patients with Guillain Barre Syndrome at a tertiary care centre in Pakistan, 1995-2003. Publishing Authors By Initials

MY Yakoob,A Rahman,B Jamil,NA Syed,

For similar bacterial infections and mycoses: infection: respiratory tract infections research abstracts see: bacterial infections and mycoses: infection: respiratory tract infections research

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Characteristics of patients with Guillain Barre Syndrome at a tertiary care centre in Pakistan, 1995-2003. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: JPMA. The Journal of the Pakistan Medical Associat

VOLUME: 55

Page Numbers: 493-6

Journal Abbreviation:

ISSN: 0030-9982

DAY: 12

MONTH: Nov

YEAR: 2005

Characteristics of patients with Guillain Barre Syndrome at a tertiary care centre in Pakistan, 1995-2003. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7501162

Characteristics of patients with Guillain Barre Syndrome at a tertiary care centre in Pakistan, 1995-2003. Keywords Mesh Terms:

KEYWORDS: Respiratory Tract Infections

MESH TERMS: complications

Chemical & Substance for Abstract: Characteristics of patients with Guillain Barre Syndrome at a tertiary care centre in Pakistan, 1995-2003. Information

Substance Name: Immunoglobulins

Registry Number: 0

Grant and Affiliation Information for Characteristics of patients with Guillain Barre Syndrome at a tertiary care centre in Pakistan, 1995-2003.

AFFILIATION: Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan.

Country: Pakistan

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MEDLINETA: J Pak Med Assoc

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