Characteristics associated with delirium in older patients in a medical intensive care unit.

Characteristics associated with delirium in older patients in a medical intensive care unit. Research Abstract Details 

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Characteristics associated with delirium in older patients in a medical intensive care unit. Abstract Text:

Margaret A Pisani,Terrence E Murphy,Peter H Van Ness,Katy L B Araujo,Sharon K Inouye,

BACKGROUND: Delirium is a highly prevalent disorder among older patients in the intensive care unit. METHODS: We performed a prospective cohort study of 304 patients 60 years or older admitted from September 5, 2002, through September 30, 2004, to a 14-bed ICU in an urban university teaching hospital. The main outcome measure was ICU delirium that developed within 48 hours of ICU admission. Patients were assessed for delirium with the Confusion Assessment Method for the ICU and medical record review. Risk factors for delirium were assessed on ICU admission by interview with proxies and medical record review. A model was developed using multivariate logistic regression and internally validated with bootstrapping methods. RESULTS: Delirium occurred in 214 study participants (70.4%) within the first 48 hours of ICU admission. In a multivariate regression model, 4 admission risk factors for delirium were identified. These risk factors included dementia (odds ratio [OR], 6.3; 95% confidence interval [CI], 2.9-13.8), receipt of benzodiazepines before ICU admission (OR, 3.4; 95% CI, 1.6-7.0), elevated creatinine level (OR, 2.1; 95% CI, 1.1-4.0), and low arterial pH (OR, 2.1; 95% CI, 1.1-3.9). The C statistic was 0.78. CONCLUSIONS: Delirium is frequent among older ICU patients. Admission characteristics can be important markers for delirium in these patients. Knowledge of these admission risk factors can prompt early correction of metabolic abnormalities and may subsequently reduce delirium duration.

Characteristics associated with delirium in older patients in a medical intensive care unit. Publishing Authors By Initials

MA Pisani,TE Murphy,PH Van Ness,KL Araujo,SK Inouye,

For similar investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: cohort studies: longitudinal studies: prospective studies research abstracts see: investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: cohort studies: longitudinal studies: prospective studies research

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Characteristics associated with delirium in older patients in a medical intensive care unit. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of internal medicine

VOLUME: 167

Page Numbers: 1629-34

Journal Abbreviation: Arch. Intern. Med.

ISSN: 0003-9926

DAY: 3

MONTH: 12

YEAR: 2007

Characteristics associated with delirium in older patients in a medical intensive care unit. Information

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LANGUAGE: eng

NlmUniqueID: 372440

Characteristics associated with delirium in older patients in a medical intensive care unit. Keywords Mesh Terms:

KEYWORDS: Prospective Studies

MESH TERMS: therapy

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Grant and Affiliation Information for Characteristics associated with delirium in older patients in a medical intensive care unit.

AFFILIATION: Pulmonary & Critical Care Section, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520-8057, USA. Margaret.Pisani@yale.edu

Country: United States

AGENCY: United States NIA

GRANT: R21AG025193

ACRONYM: AG

MEDLINETA: Arch Intern Med

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