Characteristics and outcomes of hospitalized older patients who develop hypocholesterolemia.

Characteristics and outcomes of hospitalized older patients who develop hypocholesterolemia. Research Abstract Details 

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Characteristics and outcomes of hospitalized older patients who develop hypocholesterolemia. Abstract Text:

OBJECTIVES: This research project was undertaken to determine the clinical characteristics, lipoprotein abnormalities, and outcomes of older hospitalized patients who develop hypocholesterolemia. METHODS: The project had two parts: (1) a retrospective, case-control study of 50 hospitalized patients greater than or equal to 65 years old whose serum cholesterol was normal on admission (greater than or equal to 160 mg/dL) and fell to less than or equal to 120 mg/dL during hospitalization; (2) a laboratory study of lipoproteins in 17 hospitalized patients greater than or equal to 65 years old whose cholesterol was normal on admission but fell to less than or equal to 120 mg/dL during hospitalization. RESULTS: Case-control Study--Nine percent of patients greater than or equal to 65 years old developed hypocholesterolemia while in the hospital, and these patients were more likely than controls to have undergone surgery and to have nothing by mouth for 5 days or longer. Cases had a longer length of stay, more complications, and were slightly more likely to die in the hospital than controls. LABORATORY STUDY--Hypocholesterolemic patients had low concentrations of all lipoproteins (VLDL, LDL, HDL), and the LDL and HDL were enriched in triglyceride and depleted of cholesterol ester. CONCLUSION: Acquired hypocholesterolemia is a common finding in hospitalized older patients and is associated with poor outcomes. Patients who became hypocholesterolemic in the hospital had both a low concentration of lipoprotein particles and abnormalities in lipoprotein particle composition.

Characteristics and outcomes of hospitalized older patients who develop hypocholesterolemia. Publishing Authors By Initials

For similar investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: case-control studies: retrospective studies research abstracts see: investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: case-control studies: retrospective studies research

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Characteristics and outcomes of hospitalized older patients who develop hypocholesterolemia. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Geriatrics Society

VOLUME: 39

Page Numbers: 455-61

Journal Abbreviation: J Am Geriatr Soc

ISSN: 0002-8614

DAY: 10

MONTH: May

YEAR: 1991

Characteristics and outcomes of hospitalized older patients who develop hypocholesterolemia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503062

Characteristics and outcomes of hospitalized older patients who develop hypocholesterolemia. Keywords Mesh Terms:

KEYWORDS: Retrospective Studies

MESH TERMS: blood

Chemical & Substance for Abstract: Characteristics and outcomes of hospitalized older patients who develop hypocholesterolemia. Information

Substance Name: Cholesterol

Registry Number: 57-88-5

Grant and Affiliation Information for Characteristics and outcomes of hospitalized older patients who develop hypocholesterolemia.

AFFILIATION: Department of Internal Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina.

Country: UNITED STATES

AGENCY: United States NIA

GRANT: K07 AG00421

ACRONYM: AG

MEDLINETA: J Am Geriatr Soc

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