Characteristics and outcome of anti-glomerular basement membrane disease: a single-center experience.

Characteristics and outcome of anti-glomerular basement membrane disease: a single-center experience. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Characteristics and outcome of anti-glomerular basement membrane disease: a single-center experience. Abstract Text:

Over the last 16 years we have treated 40 patients with a renal pathological diagnosis of anti-glomerular basement membrane (anti-GBM) disease. The age of presentation ranged from 18 years to 76. Males and females were equally affected. The most common presenting symptoms were anorexia and uremia. Fifty percent of the patients were oliguric at presentation and required dialysis within 24 h, while the mean serum creatinine (Cr) at presentation was 5.1 +/- 6.8 mg/dL. Sixty-two percent of the patients demonstrated evidence of pulmonary involvement. Hematuria was universally present and was macroscopic in 35% of cases. Eight-two percent of the biopsies demonstrated greater than 80% crescents. Eight patients retained independent renal function after immunosuppression with cyclophosphamide, prednisone, and plasmapheresis. No patient who presented with a Cr greater than 5 mg/dL retained renal function. Using a logistic regression model the only clinical, biochemical, or pathological factors at presentation that significantly predicted eventual need for dialysis were the serum creatinine and percentage of glomeruli with crescents. Ten patients underwent cadaveric renal transplantation, and 7 have a functioning graft for a mean of 8.2 years. None have shown evidence of recurrence of anti-GBM disease in the graft. We conclude that anti-GBM disease is an important cause of renal failure and that its prognosis is directly related to the degree of renal failure at presentation. Efforts need to be made to diagnose this condition earlier in its natural history if its prognosis is to be improved.

Characteristics and outcome of anti-glomerular basement membrane disease: a single-center experience. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Characteristics and outcome of anti-glomerular basement membrane disease: a single-center experience. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Renal failure

VOLUME: 18

Page Numbers: 105-12

Journal Abbreviation: Ren Fail

ISSN: 0886-022X

DAY: 21

MONTH: Jan

YEAR: 1996

Characteristics and outcome of anti-glomerular basement membrane disease: a single-center experience. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8701128

Characteristics and outcome of anti-glomerular basement membrane disease: a single-center experience. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: pathology

Chemical & Substance for Abstract: Characteristics and outcome of anti-glomerular basement membrane disease: a single-center experience. Information

Substance Name: Immunoglobulin G

Registry Number: 0

Grant and Affiliation Information for Characteristics and outcome of anti-glomerular basement membrane disease: a single-center experience.

AFFILIATION: Department of Renal Medicine, Beaumont Hospital, Dublin, Ireland.

Country: UNITED STATES

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Ren Fail

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Characteristics and outcome of anti-glomerular basement membrane disease: a single-center experience Related Publications

• "Sunflower cataract" in Wilson's disease.
• A CASE OF SECONDARY CARCINOMATOUS INFILTRATION OF THE PIA-ARACHNOID OF THE BRAIN, PRESENTING EXCLUSIVELY OCULAR SYMPTOMS DURING LIFE: MENINGITIS CARCINOMATOSA.
• A Phase I Study of the Safety of the Nutritional Supplement, Active Hexose Correlated Compound, AHCC, in Healthy Volunteers.
• A longitudinal study of the yield and clinical utility of a specifically designed secondary hypertension investigation protocol.
• Acrodermatitis enteropathica.
• Benign recurrent intrahepatic "obstructive" jaundice.
• Cause of death in Wilson disease.
• Characteristics and outcome of anti-glomerular basement membrane disease: a single-center experience.
• Diagnosis of hysteria.
• Disturbances of aminoacid metabolism following liver injury; a study by means of paper chromatography.
• Effect of cytomegalovirus prophylaxis with acyclovir on renal transplant survival.
• Foetor hepaticus.
• Francis Martin Rouse Walshe, 1885-1973.
• Glutamic acid in hepatic coma.
• Liver and muscle glycogen in normal subjects, in diabetes mellitus and in acute hepatitis; the effects of intravenous adrenaline.
• Liver and muscle glycogen in normal subjects, in diabetes mellitus and in acute hepatitis; under basal conditions.
• Mesangioproliferative glomerulonephritis with IgM deposition: clinical characteristics and outcome.
• Methyl mercaptan in relation to foetor hepaticus.
• Methyl mercaptan in relation to foetor hepaticus.
• Multiple myeloma and renal failure: one center's experience.
• Norwegian scabies.
• Observations on the symptomatology and pathogenesis of hepatic coma.
• On clinical medicine.
• PENICILLAMINE AND MIXED DISULPHIDE EXCRETION IN WILSON'S DISEASE.
• Primary carcinoma of the liver: description of a case with ethanolaminuria, a new and obscure metabolic defect.
• Renal failure associated with alternative medical therapies.
• The HELLP syndrome, a prospective study.
• The action of chelating agents in Wilson's disease.
• The effect of glutamic acid on the coma of hepatic failure.
• Treatment of Wilson's disease with penicillamine.