Chaperone-mediated autophagy and aging: a novel regulatory role of lipids revealed.

Chaperone-mediated autophagy and aging: a novel regulatory role of lipids revealed. Research Abstract Details 

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Chaperone-mediated autophagy and aging: a novel regulatory role of lipids revealed. Abstract Text:

Roberta Kiffin,Susmita Kaushik,Mei Zeng,Urmi Bandyopadhyay,Cong Zhang,Ashish C Massey,Marta Martinez-Vicente,Ana Maria Cuervo,

A wide pool of cytosolic proteins is selectively degraded in lysosomes by chaperonemediated autophagy (CMA). Binding of these proteins to a receptor at the lysosomal membrane is the limiting step in CMA. Levels of this receptor are tightly regulated through changes in its degradation, multimeric organization and dynamic distribution between the lysosomal membrane and lumen. We have now reported that subcompartmentalization of the receptor in discrete lipid microdomains at the lysosomal membrane regulates its engagement in each of these processes-degradation, multimerization and membrane retrieval. Changes in the lipid composition of the membrane thus affect the dynamics of the receptor and, consequently, CMA activity. As an example of CMA dysfunction resulting from perturbation of the lipid composition of the lysosomal membrane, we discuss here a second study in which we analyzed the changes in the dynamics of the receptor during aging. CMA activity decreases with age primarily due to a decrease in the levels of the CMA receptor at the lysosomal membrane. Now we have found that age-related alterations in the lipid composition of the discrete microdomains at the lysosomal membrane are behind the reduced lysosomal levels of the receptor and, consequently, the declined CMA activity that occurs during aging.

Chaperone-mediated autophagy and aging: a novel regulatory role of lipids revealed. Publishing Authors By Initials

R Kiffin,S Kaushik,M Zeng,U Bandyopadhyay,C Zhang,AC Massey,M Martinez-Vicente,AM Cuervo,

For similar proteins: molecular chaperones research abstracts see: proteins: molecular chaperones research

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Chaperone-mediated autophagy and aging: a novel regulatory role of lipids revealed. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Autophagy

VOLUME: 3

Page Numbers: 387-9

Journal Abbreviation: Autophagy

ISSN: 1554-8627

DAY: 9

MONTH: 07

YEAR: 2007

Chaperone-mediated autophagy and aging: a novel regulatory role of lipids revealed. Information

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LANGUAGE: eng

NlmUniqueID: 101265188

Chaperone-mediated autophagy and aging: a novel regulatory role of lipids revealed. Keywords Mesh Terms:

KEYWORDS: Molecular Chaperones

MESH TERMS: physiology

Chemical & Substance for Abstract: Chaperone-mediated autophagy and aging: a novel regulatory role of lipids revealed. Information

Substance Name: Molecular Chaperones

Registry Number: 0

Grant and Affiliation Information for Chaperone-mediated autophagy and aging: a novel regulatory role of lipids revealed.

AFFILIATION: Department of Anatomy and Structural Biology, Marion Bessin Liver ResearchCenter, Institute for Aging Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: T32GM007491

ACRONYM: GM

MEDLINETA: Autophagy

REFSOURCE: J Cell Sci. 2007 Mar 1;120(Pt 5):782-91

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