[Changes of T-helper 1 and T-helper 2 ratio in peripheral blood and decidua in hypertensive disorder complicating pregnancy]

[Changes of T-helper 1 and T-helper 2 ratio in peripheral blood and decidua in hypertensive disorder complicating pregnancy] Research Abstract Details 

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[Changes of T-helper 1 and T-helper 2 ratio in peripheral blood and decidua in hypertensive disorder complicating pregnancy] Abstract Text:

Ying-pu ,Wen-zhen Zhang,Shi-yan Lu,Hong Xin,

OBJECTIVE: To investigate the role of immune response induced by different T-helper 1 and T-helper 2 (Th1 and Th2) ratio in peripheral blood and decidua from patients with hypertensive disorder complicating pregnancy in the pathogenesis of the disease. METHODS: Peripheral blood and decidua from 12 non-pregnant women (no deciduas) (normal women group), 12 healthy pregnant women (healthy pregnant women group), 10 patients with gestational hypertension (gestational hypertension group), 25 patients with pre-eclampsia (PE) (including 10 patients with mild pre-eclampsia and 15 patients with severe pre-eclampsia) (pre-eclampsia group). Th1/Th2 ratio in peripheral blood and decidua was determined by flow-cytometrically. RESULTS: The ratio of Th1/Th2 in peripheral blood with normal women group is 10.5 +/- 1.5, the ratios of Th1/Th2 in peripheral blood and deciduas with healthy pregnant women group are 9.5 +/- 2.9 and 7.6 +/- 4.6 respectively, those with gestational hypertension group are 12.1 +/- 3.4 and 13.1 +/- 5.6 respectively, those with pre-eclampsia group are 16.8 +/- 3.8 and 26.7 +/- 9.4 respectively. The ratios of Th1/Th2 in peripheral blood and deciduas with pre-eclampsia group are much higher than those with other groups, when they are compared with each other, there are statistical difference (P < 0.05). And the ratio of Th1/Th2 with pre-eclampsia in deciduas is much higher than that in peripheral blood, comparing these two aspects, there is statistical difference (P < 0.001). The changes of Th1/Th2 ratio in gestational hypertension group is an intermediate between healthy pregnant group and pre-eclampsia group. CONCLUSIONS: Hypertensive disorder complicating pregnancy is a syndrome of Th1/Th2 cell balance disturbances in vivo. Over-expression of Th1 cells and imbalance of Th1/Th2 might lead to hypertensive disorder complicating pregnancy.

[Changes of T-helper 1 and T-helper 2 ratio in peripheral blood and decidua in hypertensive disorder complicating pregnancy] Publishing Authors By Initials

YP ,WZ Zhang,SY Lu,H Xin,

For similar cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd4-positive t-lymphocytes: t-lymphocytes, helper-inducer: th2 cells research abstracts see: cells: blood cells: leukocytes: leukocytes, mononuclear: lymphocytes: t-lymphocytes: cd4-positive t-lymphocytes: t-lymphocytes, helper-inducer: th2 cells research

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[Changes of T-helper 1 and T-helper 2 ratio in peripheral blood and decidua in hypertensive disorder complicating pregnancy] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua fu chan ke za zhi

VOLUME: 41

Page Numbers: 103-6

Journal Abbreviation: Zhonghua Fu Chan Ke Za Zhi

ISSN: 0529-567X

DAY: 27

MONTH: Feb

YEAR: 2006

[Changes of T-helper 1 and T-helper 2 ratio in peripheral blood and decidua in hypertensive disorder complicating pregnancy] Information

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LANGUAGE: chi

NlmUniqueID: 16210370

[Changes of T-helper 1 and T-helper 2 ratio in peripheral blood and decidua in hypertensive disorder complicating pregnancy] Keywords Mesh Terms:

KEYWORDS: Th2 Cells

MESH TERMS: immunology

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Grant and Affiliation Information for [Changes of T-helper 1 and T-helper 2 ratio in peripheral blood and decidua in hypertensive disorder complicating pregnancy]

AFFILIATION: Department of Obstetrics and Gynecology, Second Hospital, Hebei Medical University, Shijiazhuang 050000, China.

Country: China

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MEDLINETA: Zhonghua Fu Chan Ke Za Zhi

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