[Changes of phosphorylation states of Cx43 protein in CCL-64 cells induced by SiO2]

[Changes of phosphorylation states of Cx43 protein in CCL-64 cells induced by SiO2] Research Abstract Details 

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[Changes of phosphorylation states of Cx43 protein in CCL-64 cells induced by SiO2] Abstract Text:

Weiwei Wu,Guogen Mao,

OBJECTIVE: To investigate whether the cellular gap junctional communication(GJIC) down-regulation in alveolar epithelial cells (CCL-64 cells) induced by silica-stimulated pulmonary alveolar macrophages (PAM) supernatant is related with the phosphorylation states of connexin 43(Cx43) protein. METHOD: Western-blot analysis was used to identify phosphorylated Cx43 species. RESULTS: Western-blot analyses of SiO2- and phorbol 12-myristate 13-acetate(TPA)-treated CCL-64 cells showed the same phosphorylation states of Cx43 as the control group. There were no Cx43 protein in nucleus of CCL-64 cells. CONCLUSION: The inhibition on GJIC induced by SiO2 and TPA in CCL-64 cells may not be brought about by altering the phosphorylation states of Cx43.

[Changes of phosphorylation states of Cx43 protein in CCL-64 cells induced by SiO2] Publishing Authors By Initials

W Wu,G Mao,

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[Changes of phosphorylation states of Cx43 protein in CCL-64 cells induced by SiO2] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Z

VOLUME: 20

Page Numbers: 458-60

Journal Abbreviation: Zhonghua Lao Dong Wei Sheng Zh

ISSN: 1001-9391

DAY: 25

MONTH: Dec

YEAR: 2002

[Changes of phosphorylation states of Cx43 protein in CCL-64 cells induced by SiO2] Information

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LANGUAGE: chi

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AFFILIATION: Women's Hospital, Zhejiang University, School of Medicine, Hangzhou 310006, China.

Country: China

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MEDLINETA: Zhonghua Lao Dong Wei Sheng Zh

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