Objective: To study human recombination bone morphogenetic protein-2 (rhBMP-2) change in bone and marrow under simulated weightlessness. Method: 5 SD rats were tail suspended for 14, 28 d with another 5 freely active rats as control. Histological samples were in situ hybridized. Result: rhBMP-2 expression of bone and marrow were lower in tail suspended rats than control levels (P < 0.05). rhBMP-2 expression tail suspended rats in 14 day were higher than that in 28 day suspended group (P < 0.05). Conclusion: rhBMP-2 levels in rats bone and marrow were lower after tail suspension.
[Changes of human recombination bone morphogenetic protein-2 in bone and marrow in tail suspended rats] Publishing Authors By Initials