Changes of dipeptidylpeptidase IV as a membrane marker of lymphocytes in acute and chronic liver diseases--biochemical and cytochemical investigations.

Changes of dipeptidylpeptidase IV as a membrane marker of lymphocytes in acute and chronic liver diseases--biochemical and cytochemical investigations. Research Abstract Details 

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Changes of dipeptidylpeptidase IV as a membrane marker of lymphocytes in acute and chronic liver diseases--biochemical and cytochemical investigations. Abstract Text:

R Nilius,K Stuhec,R Dietrich,

Lymphocytic dipeptidylpeptidase IV (DPP-IV, E.C. 3.4.14.5) is described as a marker enzyme of immunostimulant T-lymphocytes as well as functional characteristic of interleukin-2-producing cells. Cytochemical staining of DPP-IV positive lymphocytes and measurements of DPP-IV activity in mononuclear cells and in sera of patients suffering from different kinds of liver diseases were performed to evaluate the average activities in positive cells. The results demonstrated that this serine exopeptidase exhibits extremely low activity in autoimmune chronic hepatopathies. On the contrary, hepatitis-B-associated liver diseases were connected with markedly increased values. Furthermore, significant differences of DPP-IV activity were found in different kinds of acute and chronic liver diseases. These findings are discussed in connection with the participation of dipeptidylpeptidase IV in impaired immunoregulation of the altered liver.

Changes of dipeptidylpeptidase IV as a membrane marker of lymphocytes in acute and chronic liver diseases--biochemical and cytochemical investigations. Publishing Authors By Initials

R Nilius,K Stuhec,R Dietrich,

For similar digestive system diseases: liver diseases research abstracts see: digestive system diseases: liver diseases research

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Changes of dipeptidylpeptidase IV as a membrane marker of lymphocytes in acute and chronic liver diseases--biochemical and cytochemical investigations. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Physiological research / Academia Scientiarum Bohe

VOLUME: 40

Page Numbers: 95-102

Journal Abbreviation: Physiol Res

ISSN: 0862-8408

DAY: 2

MONTH: 04

YEAR: 1991

Changes of dipeptidylpeptidase IV as a membrane marker of lymphocytes in acute and chronic liver diseases--biochemical and cytochemical investigations. Information

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LANGUAGE: eng

NlmUniqueID: 9112413

Changes of dipeptidylpeptidase IV as a membrane marker of lymphocytes in acute and chronic liver diseases--biochemical and cytochemical investigations. Keywords Mesh Terms:

KEYWORDS: Liver Diseases

MESH TERMS: immunology

Chemical & Substance for Abstract: Changes of dipeptidylpeptidase IV as a membrane marker of lymphocytes in acute and chronic liver diseases--biochemical and cytochemical investigations. Information

Substance Name: Antigens, CD26

Registry Number: EC 3.4.14.5

Grant and Affiliation Information for Changes of dipeptidylpeptidase IV as a membrane marker of lymphocytes in acute and chronic liver diseases--biochemical and cytochemical investigations.

AFFILIATION: Department of Internal Medicine, Martin-Luther-University Halle/Wittenberg, FRG.

Country: CZECH REPUBLIC

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MEDLINETA: Physiol Res

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