[Changes in the percentage of human leukocyte antigen DR in CD(+)(14) monocytes in burned patients]

[Changes in the percentage of human leukocyte antigen DR in CD(+)(14) monocytes in burned patients] Research Abstract Details 

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[Changes in the percentage of human leukocyte antigen DR in CD(+)(14) monocytes in burned patients] Abstract Text:

Jing-jie Liu,Sen Hu,Ning Dong,Dan Sun,Jia-ke Chai,Jing-min Zhu,Zhi-yong Sheng,

OBJECTIVE: To observe the changes in the percentage of CD(+)(14) monocytes expressing human leukocyte antigen DR(HLA-DR) in burn patients. METHODS: Thirty burn patients were divided into three groups according to body surface area burned: severe burn group [>60% total body surface area(TBSA)]; moderate burn group (25%-30% TBSA), mild burn group(<10% TBSA). Blood samples were collected on 3, 7, 14, 28 and 49 postburn days(PBD), and CD(+)(14) monocyte HLA-DR expression was determined with monoclonal antibody staining and flow cytometry. RESULTS: After burn injury, the percentage of monocytes expressing HLA-DR in mild burned patients was (58.80+/-5.60)%. The monocyte HLA-DR level was significantly reduced to below 30% on 3 PBD in both severely burned patients and moderately burned patients[(4.30+/-1.50)% and (13.86+/-2.40)%] respectively. The level of monocyte HLA-DR in moderately burned patients recovered on 21 PBD to above 30% while that of severely burned patients continued to be lowered till discharge from the hospital. There were statistical significant differences in HLA-DR expression between severely burned patients and moderately burned patients on 3, 7 and 14 PBD. CONCLUSION: The results suggested that immunity paralysis lasted for a long time in severely burned patients, and the percentage of monocytes expressing HLA-DR could be an important index in evaluating immune function of burn patients. Therefore, therapy to enhance immunity may be beneficial in the treatment of burn patients.

[Changes in the percentage of human leukocyte antigen DR in CD(+)(14) monocytes in burned patients] Publishing Authors By Initials

JJ Liu,S Hu,N Dong,D Sun,JK Chai,JM Zhu,ZY Sheng,

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[Changes in the percentage of human leukocyte antigen DR in CD(+)(14) monocytes in burned patients] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese cr

VOLUME: 15

Page Numbers: 23-5

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ISSN: 1003-0603

DAY: 10

MONTH: Jan

YEAR: 2003

[Changes in the percentage of human leukocyte antigen DR in CD(+)(14) monocytes in burned patients] Information

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LANGUAGE: chi

NlmUniqueID: 9887521

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AFFILIATION: Burn Institute, 304th Hospital of People's Liberation Army, Beijing 100037, China.

Country: China

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MEDLINETA: Zhongguo Wei Zhong Bing Ji Jiu

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