Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia.

Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia. Research Abstract Details 

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Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia. Abstract Text:

Delphine Poncet,Aurélie Belleville,Claire T'kint de Roodenbeke,Aude Roborel de Climens,Elsa Ben Simon,Hélène Merle-Beral,Evelyne Callet-Bauchu,Gilles Salles,Laure Sabatier,Jozo Delic,Eric Gilson,Delphine Poncet, Belleville,Claire T'kint de Roodenbeke,Aude Roborel de Climens,Elsa Ben Simon, Merle-Beral,Evelyne Callet-Bauchu,Gilles Salles,Laure Sabatier,Jozo Delic,Eric Gilson,

In this study, we explored the telomeric changes that occur in B-chronic lymphocytic leukemia (B-CLL), in which telomere length has recently been demonstrated to be a powerful prognostic marker. We carried out a transcriptomic analysis of telomerase components (hTERT and DYSKERIN), shelterin proteins (TRF1, TRF2, hRAP1, TIN2, POT1, and TPP1), and a set of multifunctional proteins involved in telomere maintenance (hEST1A, MRE11, RAD50, Ku80, and RPA1) in peripheral B cells from 42 B-CLL patients and 20 healthy donors. We found that, in B-CLL cells, the expressions of hTERT, DYSKERIN, TRF1, hRAP1, POT1, hEST1A, MRE11, RAD50, and KU80 were more than 2-fold reduced (P < .001), contrasting with the higher expression of TPP1 and RPA1 (P < .001). This differential expression pattern suggests that both telomerase down-regulation and changes in telomeric proteins composition are involved in the pathogenesis of B-CLL.

Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia. Publishing Authors By Initials

D Poncet,A Belleville,CT de Roodenbeke,AR de Climens,EB Simon,H Merle-Beral,E Callet-Bauchu,G Salles,L Sabatier,J Delic,E Gilson,D Poncet,A Belleville,CT de Roodenbeke,AR de Climens,EB Simon,H Merle-Beral,E Callet-Bauchu,G Salles,L Sabatier,J Delic,E Gilson,

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Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Blood

VOLUME: 111

Page Numbers: 2388-91

Journal Abbreviation: Blood

ISSN: 0006-4971

DAY: 12

MONTH: 12

YEAR: 2007

Changes in the expression of telomere maintenance genes suggest global telomere dysfunction in B-chronic lymphocytic leukemia. Information

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LANGUAGE: eng

NlmUniqueID: 7603509

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Country: United States

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