[Changes in the activity of platelet L-arginine/nitric oxide pathway in hypercholesterolemia patients]

[Changes in the activity of platelet L-arginine/nitric oxide pathway in hypercholesterolemia patients] Research Abstract Details 

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[Changes in the activity of platelet L-arginine/nitric oxide pathway in hypercholesterolemia patients] Abstract Text:

W Kou,S Yin,D Nie,L Ma,S Xie,Z Li,J Feng,L Xu,

OBJECTIVE: To investigate the changes of the platelet L-arginine (L-Arg)/nitric oxide (NO) pathway in hypercholesterolemia patients. METHODS: The platelet NO production in 21 hypercholesterolemia (HC) patients and 26 normal individuals was assayed by spectrum, the NOS activity and the transportation of L-Arg were determined by (3)H-labelled L-Arg. RESULTS: The NO production in hypercholesterolemic platelets [(24.06 +/- 3.70) nmol/10(8) platelets] was decreased significantly as compared with normal controls [(28.39 +/- 4.45) nmol/10(8) platelets] (P < 0.01), and so did the NOS activity [(1.46 +/- 0.47) pmol/10(8) platelets] vs (1.81 +/- 0.50) pmol/10(8) platelets]. The transportation of L-Arg by hypercholesterolemia platelets also decreased significantly than that by normal controls. The Vmax in the former [(46.84 +/- 3.39) pmol x (10(7) platelets)(-1) x min(-1)] was significantly lower than that in the latter [(53.89 +/- 3.45) pmol x (10(7) platelets)(-1) x min(-1)]. There was no difference between the two groups in K(d) (P > 0.05). CONCLUSIONS: The activity of the L-arg/NO pathway in hypercholesterolemia platelets is decreased significantly as compared with normal controls, implying that it is probably one of the reasons for the hyperactivity of hypercholesterolemia platelets.

[Changes in the activity of platelet L-arginine/nitric oxide pathway in hypercholesterolemia patients] Publishing Authors By Initials

W Kou,S Yin,D Nie,L Ma,S Xie,Z Li,J Feng,L Xu,

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[Changes in the activity of platelet L-arginine/nitric oxide pathway in hypercholesterolemia patients] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zaz

VOLUME: 22

Page Numbers: 132-4

Journal Abbreviation: Zhonghua Xue Ye Xue Za Zhi

ISSN: 0253-2727

DAY: 5

MONTH: Mar

YEAR: 2001

[Changes in the activity of platelet L-arginine/nitric oxide pathway in hypercholesterolemia patients] Information

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LANGUAGE: chi

NlmUniqueID: 8212398

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AFFILIATION: Department of Hematology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University of Medical Sciences, Guangzhou 510120, China.

Country: China

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MEDLINETA: Zhonghua Xue Ye Xue Za Zhi

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