Changes in respiratory and hemodynamic parameters during low-dose propofol sedation in combination with regional anesthesia for herniorrhaphy and genitourinary surgery in children.

Changes in respiratory and hemodynamic parameters during low-dose propofol sedation in combination with regional anesthesia for herniorrhaphy and genitourinary surgery in children. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Changes in respiratory and hemodynamic parameters during low-dose propofol sedation in combination with regional anesthesia for herniorrhaphy and genitourinary surgery in children. Abstract Text:

Silvio Zanaboni,Baruch Krauss,Raffaella Buscaglia,Claudia Montagnini,Angelo Gratarola,Jenny Gualino,Roberto Colombo,Francesco Della Corte,

BACKGROUND: Spontaneous vs mechanical ventilation during propofol sedation has been a subject of debate. We evaluated the safety of low-dose propofol sedation as an adjunct to regional anesthesia during herniorrhaphy and genitourinary surgery in infants and children. METHODS: The study was conducted in a prospective, nonrandomized manner using a consecutive sample of 62 American Society of Anesthesiologists physical status class I patients between 5 months to 11 years of age in the surgery unit of an urban University Hospital. Propofol sedation (4-8 mg x kg(-1) x h(-1) continuous infusion) was used with regional anesthesia (caudal, ilioinguinal/iliohypogastric nerve or penile block with 0.2-0.375% ropivacaine). All children were spontaneously breathing without an anesthesia circuit. Respiratory and hemodynamic parameters were continuously recorded on all patients. One-way analysis of variance (ANOVA) for repeated measurements was used to analyze changes in respiratory and hemodynamic parameters during the procedure. RESULTS: Spontaneous ventilation was maintained in all patients with minimal changes in hemodynamic parameters. Heart rate, mean arterial pressure, and P(E)CO(2) remained stable throughout the study period: 23/62 (37%) patients exhibited signs of developing intrinsic endexpiratory pressure (PEEPi) or the presence of PEEPi because of progressive reduction of expiratory time. CONCLUSIONS: Low-dose propofol sedation in combination with regional anesthesia for elective herniorrhaphy and genitourinary surgery in children maintains spontaneous ventilation and has minimal effects on hemodynamic parameters for sedation lasting <1 h. The presence of PEEPi is a relative contraindication to the use of this regimen in children with asthma or history of upper airway infections.

Changes in respiratory and hemodynamic parameters during low-dose propofol sedation in combination with regional anesthesia for herniorrhaphy and genitourinary surgery in children. Publishing Authors By Initials

S Zanaboni,B Krauss,R Buscaglia,C Montagnini,A Gratarola,J Gualino,R Colombo,FD Corte,

For similar surgical procedures, operative: urogenital surgical procedures research abstracts see: surgical procedures, operative: urogenital surgical procedures research

PUBMED ID PMID:

MEDLINE DATE:

Changes in respiratory and hemodynamic parameters during low-dose propofol sedation in combination with regional anesthesia for herniorrhaphy and genitourinary surgery in children. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Paediatric anaesthesia

VOLUME: 17

Page Numbers: 934-41

Journal Abbreviation:

ISSN: 1155-5645

DAY: 26

MONTH: Oct

YEAR: 2007

Changes in respiratory and hemodynamic parameters during low-dose propofol sedation in combination with regional anesthesia for herniorrhaphy and genitourinary surgery in children. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9206575

Changes in respiratory and hemodynamic parameters during low-dose propofol sedation in combination with regional anesthesia for herniorrhaphy and genitourinary surgery in children. Keywords Mesh Terms:

KEYWORDS: Urogenital Surgical Procedures

MESH TERMS: drug effects

Chemical & Substance for Abstract: Changes in respiratory and hemodynamic parameters during low-dose propofol sedation in combination with regional anesthesia for herniorrhaphy and genitourinary surgery in children. Information

Substance Name: Carbon Monoxide

Registry Number: 630-08-0

Grant and Affiliation Information for Changes in respiratory and hemodynamic parameters during low-dose propofol sedation in combination with regional anesthesia for herniorrhaphy and genitourinary surgery in children.

AFFILIATION: Anesthesiology and Intensive Care Unit, Università del Piemonte Orientale, Novara, Italy. vanished3@libero.it

Country: France

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Paediatr Anaesth

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Changes in respiratory and hemodynamic parameters during low-dose propofol sedation in combination with regional anesthesia for herniorrhaphy and genitourinary surgery in children Related Publications

• Changes in respiratory and hemodynamic parameters during low-dose propofol sedation in combination with regional anesthesia for herniorrhaphy and genitourinary surgery in children.
• DLX5 overexpression impairs osteogenic differentiation of human bone marrow stromal cells.
• Identity impairment and the eating disorders: content and organization of the self-concept in women with anorexia nervosa and bulimia nervosa.
• The detection of hydroxyl radicals in vivo.
• The identity impairment model: a longitudinal study of self-schemas as predictors of disordered eating behaviors.
• Vitamin C depletion is associated with alterations in blood histamine and plasma free carnitine in adults.
• [Extended operation for cancer of the splenic flexure and the descending colon.]
• [Not Available.]