Changes in PDGF expression in spared dorsal root ganglia and associated spinal dorsal horns in cats subjected to partial dorsal root ganglionectomy.

Changes in PDGF expression in spared dorsal root ganglia and associated spinal dorsal horns in cats subjected to partial dorsal root ganglionectomy. Research Abstract Details 

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Changes in PDGF expression in spared dorsal root ganglia and associated spinal dorsal horns in cats subjected to partial dorsal root ganglionectomy. Abstract Text:

Wei-Wei Sun,Jia Liu,Xu-Yang Wang,Lian-Shuang Zhang,Wei Zhang,Li-Yan Li,Hui Li,Ting-Hua Wang,

Changes in the platelet derived growth factor (PDGF) in the spared dorsal root ganglia (DRG) and associated spinal dorsal horns were evaluated in cats subjected to unilateral removal of L(1)-L(5) and L(7)-S(2) DRG, sparing the L(6) DRG. The number of PDGF immunopositive neurons and protein expression decreased significantly in the spared DRG and associated dorsal horns of the L(3) and L(6) cord segments at 3 days post-operation (dpo). It bottomed to the lowest level at 7dpo in the DRG, then returned to the control level at 14dpo; while in the L(6) dorsal horn, it rapidly increased at 7dpo and exceeded the control level at 14dpo. This showed a significant upregulation in the spared DRG and associated spinal dorsal horns, especially in the L(6) cord segment following a transient decrease. Meanwhile, a significant upregulation of PDGF mRNA was also seen in L(6) DRG and L(3) and L(6) dorsal horns at 3dpo. The upregulation of the endogenous PDGF in the said structures indicated a potential role of this factor in spinal cord plasticity after partial dorsal root ganglia removal in cats.

Changes in PDGF expression in spared dorsal root ganglia and associated spinal dorsal horns in cats subjected to partial dorsal root ganglionectomy. Publishing Authors By Initials

WW Sun,J Liu,XY Wang,LS Zhang,W Zhang,LY Li,H Li,TH Wang,

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Changes in PDGF expression in spared dorsal root ganglia and associated spinal dorsal horns in cats subjected to partial dorsal root ganglionectomy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuroscience letters

VOLUME: 431

Page Numbers: 112-7

Journal Abbreviation: Neurosci. Lett.

ISSN: 0304-3940

DAY: 8

MONTH: 12

YEAR: 2007

Changes in PDGF expression in spared dorsal root ganglia and associated spinal dorsal horns in cats subjected to partial dorsal root ganglionectomy. Information

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LANGUAGE: eng

NlmUniqueID: 7600130

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Grant and Affiliation Information for Changes in PDGF expression in spared dorsal root ganglia and associated spinal dorsal horns in cats subjected to partial dorsal root ganglionectomy.

AFFILIATION: Institute of Neuroscience, Kunming Medical College, Kunming 650031, China; Institute of Neurological Disease, West China Hospital, Sichuan University, Chengdu 610041, China.

Country: Ireland

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MEDLINETA: Neurosci Lett

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