Changes in neuropeptide expression in mice infected with prions.

Changes in neuropeptide expression in mice infected with prions. Research Abstract Details 

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Changes in neuropeptide expression in mice infected with prions. Abstract Text:

Margarita Diez,Darlene Groth,Stephen J DeArmond,Stanley B Prusiner,Tomas ,

Prion diseases are neurodegenerative disorders characterized by accumulation of an aberrantly folded isoform (PrP(Sc)) of the normal prion protein (PrP(C)). Using in situ hybridization and immunohistochemistry, we have studied changes in the expression of neuropeptides, acetylcholinesterase and tyrosine hydroxylase in CD1 and FVB wild-type mouse strains, as well as in PrP(C) null mice and in mice overexpressing PrP(C) following intracerebral inoculation with RML or Me7 prions. In the immunohistochemical analysis, neuropeptide Y (NPY), enkephalin and dynorphin-like immunoreactivities increased in mossy fibers of CD1 and FVB mice inoculated with either RML- or Me7 prions, whereas cholecystokinin-like immunoreactivity was decreased. These changes in peptide levels were paralleled by an increase in the transcripts in granule cells for neuropeptide Y, enkephalin, and cholecystokinin. However, the dynorphin transcript was decreased in the granule cells. The changes occurred more rapidly in PrP(C)-overexpressing compared to wild-type mice, and could not be found at all in PrP(C)-knockout mice. These changes in peptide expression, which mostly occur before appearance of symptoms of disease, may reflect attempts to initiate protective and/or regenerative processes.

Changes in neuropeptide expression in mice infected with prions. Publishing Authors By Initials

M Diez,D Groth,SJ DeArmond,SB Prusiner,T ,

For similar proteins: prions research abstracts see: proteins: prions research

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Changes in neuropeptide expression in mice infected with prions. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neurobiology of aging

VOLUME: 28

Page Numbers: 748-65

Journal Abbreviation: Neurobiol. Aging

ISSN: 1558-1497

DAY: 18

MONTH: 04

YEAR: 2006

Changes in neuropeptide expression in mice infected with prions. Information

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LANGUAGE: eng

NlmUniqueID: 8100437

Changes in neuropeptide expression in mice infected with prions. Keywords Mesh Terms:

KEYWORDS: Prions

MESH TERMS: toxicity

Chemical & Substance for Abstract: Changes in neuropeptide expression in mice infected with prions. Information

Substance Name: Prions

Registry Number: 0

Grant and Affiliation Information for Changes in neuropeptide expression in mice infected with prions.

AFFILIATION: Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden. Margarita.Diez@cmm.ki.se

Country: United States

AGENCY: United States NIDDK

GRANT: DK41301

ACRONYM: DK

MEDLINETA: Neurobiol Aging

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