Changes in mRNA for CAPON and Dexras1 in adult rat following sciatic nerve transection.

Changes in mRNA for CAPON and Dexras1 in adult rat following sciatic nerve transection. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Changes in mRNA for CAPON and Dexras1 in adult rat following sciatic nerve transection. Abstract Text:

Aiguo Shen,Mengling Chen,Shuqiong Niu,Linlin Sun,Shangfeng Gao,Shuxian Shi,Xin Li,Qingshan Lv,Zhiqin Guo,Chun Cheng,

Peripheral nerve transection has been implicated to cause a production of neuronal nitric oxide synthase (nNOS), which may influence a range of post-axotomy processes necessary for neuronal survival and nerve regeneration. Carboxy-terminal post synaptic density protein/Drosophila disc large tumor suppressor/zonula occuldens-1 protein (PDZ) ligand of neuronal nitric oxide synthase (CAPON), as an adaptor, interacts with nNOS via the PDZ domain helping regulate nNOS activity at postsynaptic sites in neurons. And Dexras1, a small G protein mediating multiple signal transductions, has been reported to form a complex with CAPON and nNOS. A role for the physiologic linkage by CAPON of nNOS to Dexras1 has suggested that NO-mediated activation of Dexras1 is markedly enhanced by CAPON. We investigated the changes in mRNA for CAPON, Dexras1 and nNOS in the sciatic nerve, dorsal root ganglia and lumbar spinal cord of adult rat following sciatic axotomy by TaqMan quantitative real-time PCR and in situ hybridization combined with immunofluorescence. Signals of mRNA for CAPON and Dexras1 were initially expressed in these neural tissues mentioned, transiently increased at certain time periods after sciatic axotomy and finally recovered to the basal level. It was also found that nNOS mRNA underwent a similar change pattern during this process. These results suggest that CAPON as well as Dexras1 may be involved in the different pathological conditions including nerve regeneration, neuron loss or survival and even pain process, possibly via regulating the nNOS activity or through the downstream targets of Dexras1.

Changes in mRNA for CAPON and Dexras1 in adult rat following sciatic nerve transection. Publishing Authors By Initials

A Shen,M Chen,S Niu,L Sun,S Gao,S Shi,X Li,Q Lv,Z Guo,C Cheng,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Changes in mRNA for CAPON and Dexras1 in adult rat following sciatic nerve transection. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of chemical neuroanatomy

VOLUME: 35

Page Numbers: 85-93

Journal Abbreviation: J. Chem. Neuroanat.

ISSN: 0891-0618

DAY: 31

MONTH: 07

YEAR: 2007

Changes in mRNA for CAPON and Dexras1 in adult rat following sciatic nerve transection. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8902615

Changes in mRNA for CAPON and Dexras1 in adult rat following sciatic nerve transection. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Changes in mRNA for CAPON and Dexras1 in adult rat following sciatic nerve transection. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Changes in mRNA for CAPON and Dexras1 in adult rat following sciatic nerve transection.

AFFILIATION: The Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, People's Republic of China.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Chem Neuroanat

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Changes in mRNA for CAPON and Dexras1 in adult rat following sciatic nerve transection Related Publications

• Alphavbeta integrins play an essential role in BMP-2 induction of osteoblast differentiation.
• Ethnic differences in incidence of diseases and response to medicines.
• Neurological improvement after cranioplasty - analysis by transcranial doppler ultrasonography.
• Parallel approach for solution-phase synthesis of 2-quinoxalinol analogues and their inhibition of LPS-induced TNF-alpha release on mouse macrophages in vitro.
• Regulation of bone matrix protein expression and induction of differentiation of human osteoblasts and human bone marrow stromal cells by bone morphogenetic protein-2.
• Signal transductions induced by bone morphogenetic protein-2 and transforming growth factor-beta in normal human osteoblastic cells.
• [A new approach to the fast measurement of content of amino acids in Cordyceps sinensis by ANN-NIR]
• [A strain of A/PR/8/34 (H1N1)-like virus isolated from men]
• [An overview of injectable and absorbable gelling scaffolds]
• [Analysis of single cells by capillary electrophoresis]
• [Application of biodegradable polyhydroxybutyrate in medicine and tissue engineering]
• [Bioartificial liver support system: state of the art]
• [Changes in voltage-dependent calcium channel currents of vascular smooth muscle cells isolated from small mesenteric arteries of simulated weightless rats.]
• [Determination of docosyl ferulate in extract of Pygeum africanton Hook. by high performance liquid chromatography (HPLC)]
• [Determination of mercury and selenium in bone by atomic absorption spectrometry after microwave digestion]
• [Determination of potassium, calcium, manganese, chromium and cadmium in 10 kinds of (tobacco) cigarettes by flame atomic absorption spectrophotometer]
• [Experience of ZHANG Jian-Qiu in treating "extraordinary meridian diseases" based on syndrome differentiation of miscellaneous diseases]
• [Experimental study on the myogenic differentiation of marrow mesenchymal stem cells in the local muscle tissues]
• [Expression, localization and interrelationship of P27kip1 and cyclin D3 in non-Hodgkin's lymphoma]
• [Pursue one's study and cultivate one's morality in scientific research]
• [Relation between activation of NF-kappa B and chemotherapy induced apoptosis of leukemic cells]
• [Relationship between myocyte proliferation and cardiac function in adult rats with heart failure]
• [Scatter correction of PET based on non-linear statistical estimate method]
• [Species composition and ecological distribution of planktonic diatoms in the Changjiang River estuary during spring]
• [Study on the cloning goat by cross-breed somatic cell nuclear transfer]
• [Study on the interaction of metal ion in active center of superoxide dismutase with cobalt chloride by visible spectroscopy]
• [Study on the relationship between Fas expression and apoptosis in oral squamous cell carcinoma]
• [The effects of interleukin-11 on high-dose methotrexate (HDMTX) induced mucositis in Wistar rats.]
• [The protective effect of basic fibroblast growth factor (bFGF) and electroacupuncture on neurons against cerebral ischemia]
• [The role of homeobox B2 gene in vascular endothelial proliferation and the protective effects of VEGF on the endothelia against radiation injury]