Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism.

Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism. Research Abstract Details 

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Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism. Abstract Text:

Saravanan S Karuppagounder,Qingli Shi,Hui Xu,Gary E Gibson,

Abnormalities in oxidative metabolism and reductions of thiamine-dependent enzymes accompany many age-related neurodegenerative diseases. Thiamine deficiency (TD) produces a cascade of events including mild impairment of oxidative metabolism, activation of microglia, astrocytes and endothelial cells that leads to neuronal loss in select brain regions. The earliest changes occur in a small, well-defined brain region, the submedial thalamic nucleus (SmTN). In the present study, a micropunch technique was used to evaluate quantitatively the selective regional changes in mRNA and protein levels. To test whether this method can distinguish between changes in vulnerable and non-vulnerable regions, markers for neuronal loss (NeuN) and endothelial cells (eNOS) and inflammation (IL-1beta, IL-6 and TNF-alpha) in SmTN and cortex of control and TD mice were assessed. TD significantly reduced NeuN and increased CD11b, GFAP and ICAM-1 immunoreactivity in SmTN as revealed by immunocytochemistry. When assessed on samples obtained by the micropunch method, NeuN protein declined (-49%), while increased mRNA levels were observed for eNOS (3.7-fold), IL-1beta (43-fold), IL-6 (44-fold) and TNF-alpha (64-fold) in SmTN with TD. The only TD-induced change that occurred in cortex with TD was an increase in TNF-alpha (22-fold) mRNA levels. Immunocytochemical analysis revealed that IL-1beta, IL-6 and TNF-alpha protein levels increased in TD brains and colocalized with glial markers. The consistency of these quantitative results with immunocytochemical measurements validates the micropunch technique. The results demonstrate that TD induces quantitative, distinct inflammatory responses and oxidative stress in vulnerable and non-vulnerable regions that may underlie selective vulnerability.

Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism. Publishing Authors By Initials

SS Karuppagounder,Q Shi,H Xu,GE Gibson,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

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MEDLINE DATE:

Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Neurobiology of disease

VOLUME: 26

Page Numbers: 353-62

Journal Abbreviation:

ISSN: 0969-9961

DAY: 8

MONTH: 02

YEAR: 2007

Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9500169

Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: pathology

Chemical & Substance for Abstract: Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism. Information

Substance Name: Thiamine

Registry Number: 59-43-8

Grant and Affiliation Information for Changes in inflammatory processes associated with selective vulnerability following mild impairment of oxidative metabolism.

AFFILIATION: Department of Neurology and Neuroscience, Weill Medical College of Cornell University, Burke Medical Research Institute, 785 Mamaroneck Avenue, White Plains, NY 10605, USA.

Country: United States

AGENCY: United States NIA

GRANT: AG14930

ACRONYM: AG

MEDLINETA: Neurobiol Dis

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