Changes in heart rate variability and QT dispersion in patients with overt hypothyroidism.

Changes in heart rate variability and QT dispersion in patients with overt hypothyroidism. Research Abstract Details 

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Changes in heart rate variability and QT dispersion in patients with overt hypothyroidism. Abstract Text:

Fabio Galetta,Ferdinando Franzoni,Poupak Fallahi,Leonardo Tocchini,Lara Braccini,Gino Santoro,Alessandro Antonelli,Fabio Galetta,Ferdinando Franzoni,Poupak Fallahi,Leonardo Tocchini,Lara Braccini,Gino Santoro,Alessandro Antonelli,

Objective The aim of the present study was to evaluate the effect of clinical hypothyroidism on cardiovascular autonomic function and ventricular repolarization. Design and methods We studied 31 patients (22 females and 9 males; mean age 53.6+/-11.8 years) with overt hypothyroidism (TSH=56.2+/-14.7 muU/ml, low free thyroxine (T(4)), free tri-iodothyronine (T(3))) and 31 euthyroid controls, to investigate the dispersion of the QT interval in electrocardiogram (ECG) (an index of inhomogeneity of repolarization) and heart rate variability (HRV; a measure of cardiac autonomic modulation). The hypothyroid patients and controls underwent a full medical examination, standard 12-lead ECG, and 24-h ambulatory ECG monitoring. The hypothyroid patients were re-examined after 6 months of treatment with l-T(4). Results Patients with hypothyroidism showed higher QT dispersion and lower HRV measures than controls (P<0.01 or P<0.001). In hypothyroid patients, standard deviation of all R-R intervals was inversely related (by simple regression) to serum (log)TSH levels (r=-0.47, P=0.008), while QT dispersion (r=0.50, P=0.004) and QTc dispersion (r=0.46, P=0.008) were directly related to (log)TSH. Parameters of HRV improved after 6 months of l-T(4) treatment, with the correction of hypothyroidism, becoming comparable with those of the control subjects, whereas the QT and QTc dispersion results were found to be only partially restored, remaining higher than the controls. Conclusions The results of the study demonstrate that hypothyroidism is associated with a decreased sympatho-vagal modulation of the heart rate and with an increased inhomogeneity of ventricular recovery times. The assessment of HRV and QT dispersion in patients with overt hypothyroidism may represent a useful tool in monitoring the cardiovascular risks.

Changes in heart rate variability and QT dispersion in patients with overt hypothyroidism. Publishing Authors By Initials

F Galetta,F Franzoni,P Fallahi,L Tocchini,L Braccini,G Santoro,A Antonelli,F Galetta,F Franzoni,P Fallahi,L Tocchini,L Braccini,G Santoro,A Antonelli,

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Changes in heart rate variability and QT dispersion in patients with overt hypothyroidism. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of endocrinology / European Feder

VOLUME: 158

Page Numbers: 85-90

Journal Abbreviation: Eur. J. Endocrinol.

ISSN: 1479-683X

DAY: 1

MONTH: Jan

YEAR: 2008

Changes in heart rate variability and QT dispersion in patients with overt hypothyroidism. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Changes in heart rate variability and QT dispersion in patients with overt hypothyroidism.

AFFILIATION: Department of Internal Medicine, School of Medicine, University of Pisa, Via Roma, 67, I-56100 Pisa, Italy.

Country: England

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MEDLINETA: Eur J Endocrinol

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