Changes in facial fat in HIV-related lipoatrophy, wasting, and weight gain measured by magnetic resonance imaging.

Changes in facial fat in HIV-related lipoatrophy, wasting, and weight gain measured by magnetic resonance imaging. Research Abstract Details 

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Changes in facial fat in HIV-related lipoatrophy, wasting, and weight gain measured by magnetic resonance imaging. Abstract Text:

Nicholas I Paton,Yong Yang,Naing Oo Tha,Yih-Yian Sitoh,

BACKGROUND: Changes in facial fat occurring over time in patients with HIV-related lipoatrophy have not been properly quantified. We aimed to define the longitudinal changes in facial fat compartments in patients with lipoatrophy and to compare these with changes accompanying wasting or weight gain. METHOD: Facial MRI scans were performed at baseline and repeated after a median of 10 months in 24 patients, of whom 12 had moderate to severe lipodystrophy continuing antiretroviral therapy, 5 lost weight, and 7 gained weight (more than 10% weight change). RESULTS: Superficial facial fat decreased by a median of 5.2 mL (p = .03) in patients with lipoatrophy, and 8 of 12 individuals showed more than 15% decrease (all of whom were taking stavudine). The decrease was mainly cheek fat. Superficial facial fat decreased by 6.0 mL in patients with weight loss (p = .04) and increased by 20.2 mL (p = .02) in patients with weight gain, and changes occurred in cheek fat, temporal fat, and masseter muscle and temporalis muscle compartments. CONCLUSION: MRI can detect substantial ongoing changes in facial fat in patients with facial lipoatrophy. A characteristic pattern of compartmental change distinguishes lipoatrophy from wasting and weight recovery. MRI should be considered for use in clinical trials of interventions to prevent or treat lipoatrophy and may be useful for documenting changes in individual patients during clinical follow-up.

Changes in facial fat in HIV-related lipoatrophy, wasting, and weight gain measured by magnetic resonance imaging. Publishing Authors By Initials

NI Paton,Y Yang,NO Tha,YY Sitoh,

For similar pathological conditions, signs and symptoms: signs and symptoms: body weight: body weight changes: weight loss research abstracts see: pathological conditions, signs and symptoms: signs and symptoms: body weight: body weight changes: weight loss research

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Changes in facial fat in HIV-related lipoatrophy, wasting, and weight gain measured by magnetic resonance imaging. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: HIV clinical trials

VOLUME: 8

Page Numbers: 227-34

Journal Abbreviation:

ISSN: 1528-4336

DAY: 27

MONTH: 11

YEAR: 2007

Changes in facial fat in HIV-related lipoatrophy, wasting, and weight gain measured by magnetic resonance imaging. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100936377

Changes in facial fat in HIV-related lipoatrophy, wasting, and weight gain measured by magnetic resonance imaging. Keywords Mesh Terms:

KEYWORDS: Weight Loss

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: Changes in facial fat in HIV-related lipoatrophy, wasting, and weight gain measured by magnetic resonance imaging. Information

Substance Name: Stavudine

Registry Number: 3056-17-5

Grant and Affiliation Information for Changes in facial fat in HIV-related lipoatrophy, wasting, and weight gain measured by magnetic resonance imaging.

AFFILIATION: Infectious Disease Research Centre, Tan Tock Seng Hospital, Singapore. nick.paton@ctu.mrc.ac.uk

Country: United States

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MEDLINETA: HIV Clin Trials

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