Changes in coronary arterial dimensions early after cardiac transplantation.

Changes in coronary arterial dimensions early after cardiac transplantation. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Changes in coronary arterial dimensions early after cardiac transplantation. Abstract Text:

William F Fearon,Luciano Potena,Atsushi Hirohata,Ryota Sakurai,Masao Yamasaki,Helen Luikart,Julia Lee,Marcy L Vana,John P Cooke,Edward S Mocarski,Alan C Yeung,Hannah A Valantine,

BACKGROUND: Significant changes in coronary artery structure, including intimal thickening and vessel remodeling, occur early after cardiac transplantation. The degree to which these changes compromise coronary lumen dimensions, and the clinical factors that affect these changes, remain controversial. METHODS: Thirty-eight adult cardiac transplant recipients underwent coronary angiography and volumetric intravascular ultrasound (IVUS) evaluation of the left anterior descending artery within 8 weeks of transplantation and at 1 year. Clinical parameters including donor and recipient characteristics, rejection episodes, and serology were prospectively recorded. Two-dimensional IVUS measurements and vessel, lumen and plaque volume were calculated at both time points and compared. Multivariate regression analysis was performed to reveal clinical predictors of change in coronary dimensions. RESULTS: During the first year after transplantation, significant decreases in vessel size (negative remodeling) and lumen size were observed with significant increases in plaque burden based on IVUS analyses. Loss of lumen volume correlated significantly with the degree of negative remodeling (R=0.82, P<0.0001), but not with changes in plaque burden (R=0.08, P=0.64). Patients with the greatest increase in plaque volume had significantly less negative remodeling (R=0.53, P=0.0006). Transplant recipient cytomegalovirus (CMV) antibody seropositivity and lack of aggressive prophylaxis against CMV infection/reactivation were significant independent predictors of greater negative remodeling (P<0.01 and P=0.03, respectively) and greater lumen loss (P=0.02 and P=0.03, respectively). CONCLUSION: Negative remodeling is primarily responsible for coronary artery lumen loss during the first year after cardiac transplantation. CMV seropositivity and lack of aggressive CMV prophylaxis correlate with increased negative remodeling, resulting in greater lumen loss.

Changes in coronary arterial dimensions early after cardiac transplantation. Publishing Authors By Initials

WF Fearon,L Potena,A Hirohata,R Sakurai,M Yamasaki,H Luikart,J Lee,ML Vana,JP Cooke,ES Mocarski,AC Yeung,HA Valantine,

For similar diagnosis: diagnostic techniques and procedures: diagnostic imaging: ultrasonography: ultrasonography, interventional research abstracts see: diagnosis: diagnostic techniques and procedures: diagnostic imaging: ultrasonography: ultrasonography, interventional research

PUBMED ID PMID:

MEDLINE DATE:

Changes in coronary arterial dimensions early after cardiac transplantation. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Transplantation

VOLUME: 83

Page Numbers: 700-5

Journal Abbreviation:

ISSN: 0041-1337

DAY: 27

MONTH: Mar

YEAR: 2007

Changes in coronary arterial dimensions early after cardiac transplantation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 132144

Changes in coronary arterial dimensions early after cardiac transplantation. Keywords Mesh Terms:

KEYWORDS: Ultrasonography, Interventional

MESH TERMS: ultrasonography

Chemical & Substance for Abstract: Changes in coronary arterial dimensions early after cardiac transplantation. Information

Substance Name: Ganciclovir

Registry Number: 82410-32-0

Grant and Affiliation Information for Changes in coronary arterial dimensions early after cardiac transplantation.

AFFILIATION: Division of Cardiovascular Medicine, Stanford University Medical Center, Stanford, CA 94305-5637, USA. wfearon@stanford.edu

Country: United States

AGENCY: United States NIAID

GRANT: 1 P01 AI50153

ACRONYM: AI

MEDLINETA: Transplantation

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Changes in coronary arterial dimensions early after cardiac transplantation Related Publications

• Cardiac allograft vasculopathy and insulin resistance-hope for new therapeutic targets.
• Changes in coronary arterial dimensions early after cardiac transplantation.
• Cytomegalovirus-associated allograft rejection in heart transplant patients.
• Interplay between systemic inflammation and markers of insulin resistance in cardiovascular prognosis after heart transplantation.
• Multidisciplinary insights on clinical guidance for the use of proliferation signal inhibitors in heart transplantation.
• Peripheral blood leukocyte counts in cytomegalovirus infected heart transplant patients: impact of acute disease versus subclinical infection.