Changes in control of renin release in congestive heart failure in dogs: response to acute and chronic vasodilator therapy.

Changes in control of renin release in congestive heart failure in dogs: response to acute and chronic vasodilator therapy. Research Abstract Details 

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Changes in control of renin release in congestive heart failure in dogs: response to acute and chronic vasodilator therapy. Abstract Text:

R Engler,H Pouleur,J Link,M Printz,J W Covell,

Neural control of renin secretion is an important physiologic mechanism, but alterations in the central nervous system feedback and control of renin release in heart failure have not been investigated. Accordingly we studied conscious dogs after volume overload (arteriovenous fistula) or chronic myocardial infarction. Acute infusion of nitroprusside was used to test the renin response to arterial hypotension and decreased central blood volume. Hydralazine and prazosin administration were used to test the response to chronic vasodilator administration. After 4 weeks of volume overload or 3 weeks after myocardial infarction, the renin response to a graded hypotensive stimulus was blunted. After 7 days of hydralazine or prazosin administration, plasma renin activity remained elevated and blood volume increased from baseline values. Our results indicate a decrease in the neural feedback control of renin release after chronic volume overload or myocardial infarction. However, chronic vasodilator administration still resulted in sustained augmented renin secretion and an increase in blood volume.

Changes in control of renin release in congestive heart failure in dogs: response to acute and chronic vasodilator therapy. Publishing Authors By Initials

R Engler,H Pouleur,J Link,M Printz,JW Covell,

For similar chemical actions and uses: pharmacologic actions: therapeutic uses: cardiovascular agents: vasodilator agents research abstracts see: chemical actions and uses: pharmacologic actions: therapeutic uses: cardiovascular agents: vasodilator agents research

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Changes in control of renin release in congestive heart failure in dogs: response to acute and chronic vasodilator therapy. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Clinical and experimental hypertension. Part A, Th

VOLUME: 4

Page Numbers: 639-59

Journal Abbreviation:

ISSN: 0730-0077

DAY: 12

MONTH: 02

YEAR: 1982

Changes in control of renin release in congestive heart failure in dogs: response to acute and chronic vasodilator therapy. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8207790

Changes in control of renin release in congestive heart failure in dogs: response to acute and chronic vasodilator therapy. Keywords Mesh Terms:

KEYWORDS: Vasodilator Agents

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Changes in control of renin release in congestive heart failure in dogs: response to acute and chronic vasodilator therapy. Information

Substance Name: Renin

Registry Number: EC 3.4.23.15

Grant and Affiliation Information for Changes in control of renin release in congestive heart failure in dogs: response to acute and chronic vasodilator therapy.

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Country: UNITED STATES

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MEDLINETA: Clin Exp Hypertens A

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