Changes in aquaporin expression in the inner ear of the rat after i.p. injection of steroids.

Changes in aquaporin expression in the inner ear of the rat after i.p. injection of steroids. Research Abstract Details 

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Changes in aquaporin expression in the inner ear of the rat after i.p. injection of steroids. Abstract Text:

Munehisa Fukushima,Tadashi Kitahara,Yuka Fuse,Yoshihiro Uno,Katsumi Doi,Takeshi Kubo,

The aquaporins (AQPs) are a family of small transmembrane water transporters. It has recently been revealed that they play a role in regulating homeostasis in the inner ear fluids. Steroid therapy is usually administered to patients with inner ear disorders; however, the mechanism of steroid effects has not been clearly determined. To elucidate the points of action of steroids in the inner ear, we recently examined the distributions of AQP isoform mRNAs in the rat inner ear and identified AQP1-6 mRNAs in the rat cochlea and AQP1, 3, 4, 5 and 6 mRNAs in the rat endolymphatic sac by means of reverse transcriptase polymerase chain reaction (PCR). In this study, we investigated changes in expression of AQP mRNAs in the rat inner ear after i.p. injections of steroids using real-time quantitative PCR and found that AQP3 mRNA in the endolymphatic sac was significantly upregulated in both dose- and time-dependent manners. This result suggests that steroids may effect water homeostasis in the rat inner ear via AQPs.

Changes in aquaporin expression in the inner ear of the rat after i.p. injection of steroids. Publishing Authors By Initials

M Fukushima,T Kitahara,Y Fuse,Y Uno,K Doi,T Kubo,

For similar polycyclic compounds: steroids research abstracts see: polycyclic compounds: steroids research

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Changes in aquaporin expression in the inner ear of the rat after i.p. injection of steroids. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta oto-laryngologica. Supplementum

VOLUME:

Page Numbers: 13-8

Journal Abbreviation:

ISSN: 0365-5237

DAY: 13

MONTH: Aug

YEAR: 2004

Changes in aquaporin expression in the inner ear of the rat after i.p. injection of steroids. Information

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LANGUAGE: eng

NlmUniqueID: 370355

Changes in aquaporin expression in the inner ear of the rat after i.p. injection of steroids. Keywords Mesh Terms:

KEYWORDS: Steroids

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Changes in aquaporin expression in the inner ear of the rat after i.p. injection of steroids. Information

Substance Name: Dexamethasone

Registry Number: 50-02-2

Grant and Affiliation Information for Changes in aquaporin expression in the inner ear of the rat after i.p. injection of steroids.

AFFILIATION: Department of Otolaryngology and Sensory Organ Surgery, Osaka University Graduate School of Medicine, Japan. mfukushima@ent.med.osaka-u.ac.jp

Country: Norway

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MEDLINETA: Acta Otolaryngol Suppl

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