Changes in adrenoreceptors in the prefrontal cortex of subjects with dementia: evidence of compensatory changes.

Changes in adrenoreceptors in the prefrontal cortex of subjects with dementia: evidence of compensatory changes. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Changes in adrenoreceptors in the prefrontal cortex of subjects with dementia: evidence of compensatory changes. Abstract Text:

P Szot,S S White,J L Greenup,J B Leverenz,E R Peskind,M A Raskind,

In Alzheimer's disease (AD) there is a significant loss of locus coeruleus (LC) noradrenergic neurons. However, recent work has shown the surviving noradrenergic neurons to display many compensatory changes, including axonal sprouting to the hippocampus. The prefrontal cortex (PFC) is a forebrain region that is affected in dementia, and receives innervation from the LC noradrenergic neurons. Reduced PFC function can reduce cognition and disrupt behavior. Because the PFC is an important area in AD, we determined if noradrenergic innervation from the LC noradrenergic neurons is maintained and if adrenoreceptors are altered postsynaptically. Presynaptic PFC alpha2-adrenoreceptor (AR) binding site density, as determined by 3H-RX821002, suggests that axons from surviving noradrenergic neurons in the LC are sprouting to the PFC of subjects with dementia. Changes in postsynaptic alpha1-AR in the PFC of subjects with dementia indicate normal to elevated levels of binding sites. Expression of alpha1-AR subtypes (alpha1A- and alpha1D-AR) and alpha2C-AR subtype mRNA in the PFC of subjects with dementia is similar to what was observed in the hippocampus with one exception, the expression of alpha1A-AR mRNA. The expression of the alpha1A-AR mRNA subtype is significantly reduced in specific layers of the PFC in subjects with dementia. The loss of alpha1A-, alpha1D- and alpha2C-AR mRNA subtype expression in the PFC may be attributed to neuronal loss observed in dementia. These changes in postsynaptic AR would suggest a reduced function of the PFC. Consequence of this reduced function of the PFC in dementia is still unknown but it may affect memory and behavior.

Changes in adrenoreceptors in the prefrontal cortex of subjects with dementia: evidence of compensatory changes. Publishing Authors By Initials

P Szot,SS White,JL Greenup,JB Leverenz,ER Peskind,MA Raskind,

For similar proteins: membrane proteins: receptors, cell surface: receptors, biogenic amine: receptors, catecholamine: receptors, adrenergic research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, biogenic amine: receptors, catecholamine: receptors, adrenergic research

PUBMED ID PMID:

MEDLINE DATE:

Changes in adrenoreceptors in the prefrontal cortex of subjects with dementia: evidence of compensatory changes. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Neuroscience

VOLUME: 146

Page Numbers: 471-80

Journal Abbreviation:

ISSN: 0306-4522

DAY: 26

MONTH: 02

YEAR: 2007

Changes in adrenoreceptors in the prefrontal cortex of subjects with dementia: evidence of compensatory changes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7605074

Changes in adrenoreceptors in the prefrontal cortex of subjects with dementia: evidence of compensatory changes. Keywords Mesh Terms:

KEYWORDS: Receptors, Adrenergic

MESH TERMS: metabolism

Chemical & Substance for Abstract: Changes in adrenoreceptors in the prefrontal cortex of subjects with dementia: evidence of compensatory changes. Information

Substance Name: Idazoxan

Registry Number: 79944-58-4

Grant and Affiliation Information for Changes in adrenoreceptors in the prefrontal cortex of subjects with dementia: evidence of compensatory changes.

AFFILIATION: Northwest Network for Mental Illness Research, Education, and Clinical Center, Veterans Administration Puget Sound Health Care System, and Department of Psychiatry and Behavioral Science, University of Washington, Seattle 98195, USA. szot@u.washington.edu

Country: United States

AGENCY: United States NIA

GRANT: P50 AG005136

ACRONYM: AG

MEDLINETA: Neuroscience

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Changes in adrenoreceptors in the prefrontal cortex of subjects with dementia: evidence of compensatory changes Related Publications

• Antidepressant-resistant depression in the elderly.
• Biological markers and diagnostic accuracy in the genetics of posttraumatic stress disorder.
• Changes in adrenoreceptors in the prefrontal cortex of subjects with dementia: evidence of compensatory changes.
• Characterization of verbal and spatial memory changes from moderate to supraphysiological increases in serum testosterone in healthy older men.
• Depression in older persons: diagnosis and management.
• Electroconvulsive therapy in the elderly.
• Evaluation of candidate genes for DYX1 and DYX2 in families with dyslexia.
• Genome scan of a nonword repetition phenotype in families with dyslexia: evidence for multiple Loci.
• Linkage analyses of four regions previously implicated in dyslexia: confirmation of a locus on chromosome 15q.
• Nonnightmare distressed awakenings in veterans with posttraumatic stress disorder: response to prazosin.
• Screening for depression in hospitalized geriatric medical patients.
• Sensorineural deafness, distinctive facial features, and abnormal cranial bones: a new variant of Waardenburg syndrome?
• Suicide in two patients with Alzheimer's disease.
• Symptomatic depression in elderly medical outpatients. I. Prevalence, demography, and health service utilization.
• Treatment of acute head injuries.