[Change of nuclear factor-kappaB activity in early burn injury and its significance]

[Change of nuclear factor-kappaB activity in early burn injury and its significance] Research Abstract Details 

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[Change of nuclear factor-kappaB activity in early burn injury and its significance] Abstract Text:

Jian-kun Liao,Hong-mei Liao,Xue-hong Luo,

OBJECTIVE: To study the change of nuclear factor-kappaB(NF-kappaB) activity in the blood leukocytes of rats in the early period after severe burn injury and its significance. METHODS: To examine the change of NF-kappaB activity in leukocytes of blood of rats in the early period(48 hours) after severe burn injury to show its relation with tumor necrosis factor-alpha(TNF-alpha) and intercellular adhesion molecule-1(ICAM-1). RESULTS: The activity of NF-kappaB after burn injury was increased than that was before burn injury, and reached the peak at the 12 hours. TNF-alpha, ICAM-1 and polymorphonuclear neutrophilic leucocytes(PMN) in plasma had the similar changeable patterns, and NF-kappaB had the positive correlation with TNF-alpha, ICAM-1 and PMN. CONCLUSION: The activity of NF-kappaB is increased in blood leukocytes in the early period after severe burn injury. It may play an important role in systemic inflammatory response syndrome(SIRS) and multiple organ dysfunction syndrome(MODS) after burn injury.

[Change of nuclear factor-kappaB activity in early burn injury and its significance] Publishing Authors By Initials

JK Liao,HM Liao,XH Luo,

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[Change of nuclear factor-kappaB activity in early burn injury and its significance] Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Zhongguo wei zhong bing ji jiu yi xue = Chinese cr

VOLUME: 15

Page Numbers: 220-1

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ISSN: 1003-0603

DAY: 14

MONTH: Apr

YEAR: 2003

[Change of nuclear factor-kappaB activity in early burn injury and its significance] Information

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LANGUAGE: chi

NlmUniqueID: 9887521

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Grant and Affiliation Information for [Change of nuclear factor-kappaB activity in early burn injury and its significance]

AFFILIATION: Emergency Department, Guangdong Provincial Crops Hospital, Chinese People's Armed Police Forces, Guangzhou 510507, Guangdong, China.

Country: China

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MEDLINETA: Zhongguo Wei Zhong Bing Ji Jiu

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