Change in Ucp1 mRNA Expression Following Long-Term Cold Exposure under Normal or High-Fat Diet Regimes in the Cold-Intolerant Mammal, Suncus murinus.

Change in Ucp1 mRNA Expression Following Long-Term Cold Exposure under Normal or High-Fat Diet Regimes in the Cold-Intolerant Mammal, Suncus murinus. Research Abstract Details 

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Change in Ucp1 mRNA Expression Following Long-Term Cold Exposure under Normal or High-Fat Diet Regimes in the Cold-Intolerant Mammal, Suncus murinus. Abstract Text:

Daisuke Suzuki,Yoshiharu Murata,Sen-Ichi Oda,

The house musk shrew (Suncus murinus), or suncus, is a unique experimental mammal that is cold intolerant. However, even basic knowledge of brown adipose tissue (BAT), which is important for non-shivering thermogenesis (NST), is minimal. Therefore, we exposed suncus for 18 days to mild cold temperatures (8-14 degrees C) and/or a high-fat diet, which are factors that increase NST, and measured two mRNAs that are critical for NST in BAT, uncoupling protein 1 (Ucp1) and type II 5'-deiodinase (D2). Neither mild cold exposure nor a high-fat diet alone induced up-regulation of the mRNAs. However, combinations of cold exposure and high-fat diet significantly increased both mRNAs. Therefore, cold intolerance in suncus may be partly caused by dietary components.

Change in Ucp1 mRNA Expression Following Long-Term Cold Exposure under Normal or High-Fat Diet Regimes in the Cold-Intolerant Mammal, Suncus murinus. Publishing Authors By Initials

D Suzuki,Y Murata,S Oda,

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Change in Ucp1 mRNA Expression Following Long-Term Cold Exposure under Normal or High-Fat Diet Regimes in the Cold-Intolerant Mammal, Suncus murinus. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental animals / Japanese Association for La

VOLUME: 55

Page Numbers: 467-71

Journal Abbreviation: Exp. Anim.

ISSN: 1341-1357

DAY: 8

MONTH: Oct

YEAR: 2006

Change in Ucp1 mRNA Expression Following Long-Term Cold Exposure under Normal or High-Fat Diet Regimes in the Cold-Intolerant Mammal, Suncus murinus. Information

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LANGUAGE: eng

NlmUniqueID: 9604830

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AFFILIATION: Laboratory of Animal Management & Resources, School of Bio-Agricultural Sciences.

Country: Japan

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