Chaga mushroom (Inonotus obliquus) induces G(0)/G(1) arrest and apoptosis in human hepatoma HepG2 cells.

Chaga mushroom (Inonotus obliquus) induces G(0)/G(1) arrest and apoptosis in human hepatoma HepG2 cells. Research Abstract Details 

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Chaga mushroom (Inonotus obliquus) induces G(0)/G(1) arrest and apoptosis in human hepatoma HepG2 cells. Abstract Text:

Myung-Ja Youn,Jin-Kyung Kim,Seong-Yeol Park,Yunha Kim,Se-Jin Kim,Jin-Seok Lee,Kyu-Yun Chai,Hye-Jung Kim,Ming-Xun Cui,Hong-Seob So,Ki-Young Kim,Raekil Park,Myung-Ja Youn,Jin-Kyung Kim,Seong-Yeol Park,Yunha Kim,Se-Jin Kim,Jin-Seok Lee,Kyu-Yun Chai,Hye-Jung Kim,Ming-Xun Cui,Hong-Seob So,Ki-Young Kim,Raekil Park,

AIM: To investigate the anti-proliferative and apoptotic effects of Chaga mushroom (Inonotus obliquus) water extract on human hepatoma cell lines, HepG2 and Hep3B cells. METHODS: The cytotoxicity of Chaga extract was screened by 3-[4,5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide (MTT) assay. Morphological observation, flow cytometry analysis, Western blot were employed to elucidate the cytotoxic mechanism of Chaga extract. RESULTS: HepG2 cells were more sensitive to Chaga extract than Hep3B cells, as demonstrated by markedly reduced cell viability. Chaga extract inhibited the cell growth in a dose-dependent manner, which was accompanied with G(0)/G(1)-phase arrest and apoptotic cell death. In addition, G(0)/G(1) arrest in the cell cycle was closely associated with down-regulation of p53, pRb, p27, cyclins D1, D2, E, cyclin-dependent kinase (Cdk) 2, Cdk4, and Cdk6 expression. CONCLUSION: Chaga mushroom may provide a new therapeutic option, as a potential anticancer agent, in the treatment of hepatoma.

Chaga mushroom (Inonotus obliquus) induces G(0)/G(1) arrest and apoptosis in human hepatoma HepG2 cells. Publishing Authors By Initials

MJ Youn,JK Kim,SY Park,Y Kim,SJ Kim,JS Lee,KY Chai,HJ Kim,MX Cui,HS So,KY Kim,R Park,MJ Youn,JK Kim,SY Park,Y Kim,SJ Kim,JS Lee,KY Chai,HJ Kim,MX Cui,HS So,KY Kim,R Park,

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Chaga mushroom (Inonotus obliquus) induces G(0)/G(1) arrest and apoptosis in human hepatoma HepG2 cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: World journal of gastroenterology : WJG

VOLUME: 14

Page Numbers: 511-7

Journal Abbreviation: World J. Gastroenterol.

ISSN: 1007-9327

DAY: 28

MONTH: Jan

YEAR: 2008

Chaga mushroom (Inonotus obliquus) induces G(0)/G(1) arrest and apoptosis in human hepatoma HepG2 cells. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Chaga mushroom (Inonotus obliquus) induces G(0)/G(1) arrest and apoptosis in human hepatoma HepG2 cells.

AFFILIATION: Vestibulocochlear Research Center, Wonkwang University School of Medicine, #344-2, Shinyoung-dong, Iksan, Jeonbuk 570-749, Korea. rkpark@wku.ac.kr.

Country: China

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MEDLINETA: World J Gastroenterol

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